84401-11-6Relevant articles and documents
Preparation method 3 - (trifluoromethyl) -4 -indolinic acid
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Paragraph 0059-0061; 0072-0073, (2021/09/15)
The invention discloses a preparation method of 3 - (trifluoromethyl) -4 -indolinic acid. The method comprises the following steps: (1) protecting the indole 4 - formic acid through a benzyl protecting carboxylic acid to obtain the compound shown in the formula 1. (2): The compound represented by Formula 1 is protected by an amino group to obtain a compound represented by Formula 2. (3): The compound represented by Formula 2 is substituted with iodine to obtain a compound represented by Formula 3. (4): A compound represented by Formula 3 is mixed with a trifluoromethylation reagent to react to obtain a compound having the structure shown in Formula 4. (5) The compound of formula 4 was subjected to deamination protection and benzyl to give 3 - (trifluoromethyl) -4 -indolinic acid.
Synthesis of N-Alkyl Derivatives of 4-(2'-Aminoethyl)indole
Cannon, Joseph G.,Demopoulos, Basil J.
, p. 1195 - 1199 (2007/10/02)
N-Substituted 4-(2'-aminoethyl)indoles are attainable in good yields from indole-4-acetic acid (2).Several methods of preparation for 2 were tried or considered.A new sequence involving Arndt-Eistert homologation of indole-4-carboxylic acid has been devis
