844443-90-9

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[[[4-[(2,6-dichlorobenzoyl)amino]-1H-pyrazol-3-yl]carbonyl]amino]-, 1,1-dimethylethyl ester
• CAS NO: 844443-90-9
• Molecular Formula: C21H25Cl2N5O4
• Molecular Weight: 482.367
• Mol File: 844443-90-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[[[4-[(2,6-dichlorobenzoyl)amino]-1H-pyrazol-3-yl]carbonyl]amino]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[[[4-[(2,6-dichlorobenzoyl)amino]-1H-pyrazol-3-yl]carbonyl]amino]-, 1,1-dimethylethyl ester(844443-90-9)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[[[4-[(2,6-dichlorobenzoyl)amino]-1H-pyrazol-3-yl]carbonyl]amino]-, 1,1-dimethylethyl ester(844443-90-9)

Safety Data

• Hazardous Substances Data: 844443-90-9(Hazardous Substances Data)

Usage

Molecular structure

1-Piperidinecarboxylic acid, 4-[[[4-[(2,6-dichlorobenzoyl)amino]-1H-pyrazol-3-yl]carbonyl]amino]-, 1,1-dimethylethyl ester features a piperidine ring, a pyrazole ring, and a benzoyl group.

Functional groups

The compound contains various functional groups, including an amino group, a carbonyl group, and a tert-butyl ester group.

Use in organic synthesis

Boc-D-Phe-Cis-OtBu is used as a building block in the synthesis of peptides and other bioactive molecules, due to its ability to modify the activity and properties of biological compounds.

Protection during synthesis

As a tert-butyl ester, Boc-D-Phe-Cis-OtBu offers protection to the functional groups during synthesis and can be later removed to reveal the free carboxylic acid.

Pharmaceutical research

The compound is widely used in pharmaceutical research for the development of new drugs and chemical compounds.

Derivative of piperidinecarboxylic acid

Boc-D-Phe-Cis-OtBu is a derivative of piperidinecarboxylic acid, which is a fundamental building block in the synthesis of various pharmaceutical compounds.

Molecular weight

The molecular weight of Boc-D-Phe-Cis-OtBu is 534.33 g/mol.

Upstream product

• 844443-80-7 4-[(4-nitro-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester 
• 825619-04-3 4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylic acid 
• 7719-09-7 thionyl chloride 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 1002114-29-5 4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid 
• 844443-81-8 4-[(4-amino-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester 
• 50-30-6 2,6-dichlorobenzoic acid 

Downstream Products

• 844442-38-2 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide 
• 902135-91-5 AT7519 

Relevant articles and documents

Tartaric acid addition salt of 3,4-disubstituted 1H-pyrazole compound and crystal form thereof

The invention provides one or more pharmaceutical composition of 4-(2,6-dichloro-benzoyl) amino)-1H-pyrazole-3-formate piperidine-4-yl-acyl tartaric acid addition salt, a crystallization form of the tartaric acid addition salt and use of the tartaric acid

PHARMACEUTICAL COMBINATIONS

The invention provides combinations of an ancillary compound of the formula (0): and a compound of the formula (I'): Also provided are crystalline forms of the constituent compounds, methods for making them and their uses in treating cancers.

MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS

The invention provides the use of a compound for the manufacture of a medicament for the treatment of pain, wherein the compound is a compound of the formula (0) : or a salt or tautomers or N-oxides or solvate thereof; wherein X is a group R1-A