84468-17-7

Basic information

• Product Name: H-9 2HCL
• Synonyms: H-9 2HCL;H-9, DiHCl;(2-Aminoethyl)(5-isoquinolylsulfonyl)amine;Aids108014;Aids-108014;Isoquinoline-5-sulfonic Acid N-(2-AMinoethyl)aMide;N-(2-AMinoethyl)-5-isoquinolinesulfonic Acid AMide;H-9 dihydrochloride,N-(2-Aminoethyl)-5-isoquinolinesulfonamidedihydrochloride
• CAS NO: 84468-17-7
• Molecular Formula: C₁₁H₁₃N₃O₂S
• Molecular Weight: 251.31
• Product Categories: All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators;Protein Kinase
• Mol File: 84468-17-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 110-112°C
• Boiling Point: 479.8 °C at 760 mmHg
• Flash Point: 243.9 °C
• Appearance: yellow solid
• Density: 1.339 g/cm³
• Vapor Pressure: 2.3E-09mmHg at 25°C
• Storage Temp.: −20°C
• CAS DataBase Reference: H-9 2HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-9 2HCL(84468-17-7)
• EPA Substance Registry System: H-9 2HCL(84468-17-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 84468-17-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

The free base of H-9

Biological Activity

Protein kinase inhibitor. Inhibits PKA (K i = 1.9 μ M), PKG (K i = 0.9 μ M), CaMK II (K i = 60 μ M), PKC (K i = 18 μ M), casein kinase I (K i = 110 μ M) and casein kinase II (K i > 300 μ M).

InChI:InChI=1/C11H13N3O2S/c12-5-7-14-17(15,16)11-3-1-2-9-8-13-6-4-10(9)11/h1-4,6,8,14H,5,7,12H2/p+1

Upstream product

• 27655-40-9 isoquinoline-5-sulfonic acid 
• 107-15-3 ethylenediamine 
• 651309-72-7 tert-butyl (N-(2-aminoethyl)-5-isoquinolinesulfonamide)carbamate 
• 105627-79-0 isoquinoline-5-sulfonyl chloride hydrochloride 
• 84468-15-5 5-isoquinolinesulfonyl chloride 

Downstream Products

• 1453814-94-2 N-{2-[(isoquinoline-5-sulfonyl)amino]ethyl}cyclohexanecarboxamide 
• 1453814-95-3 C₁₈H₁₇N₃O₄S 

Relevant articles and documents

Small-molecule inhibitor of protein kinase A as well as preparation method and application thereof

The invention discloses a small-molecule inhibitor of histone kinase A. The small-molecule inhibitor comprises an H89 isoquinoline precursor structure, the specific molecular formula is CxHyAzNmOnS, and in the molecular formula, x is 20 or 21, y is 20 or 22, A is F, z is 0 or 1, m is 3 or 4, and n is 2 or 4. The invention further provides small-molecule inhibitors HF89, HFC and HN89, and a PET tracer [ C] HF. The invention also provides a preparation method and an application of the related small-molecule inhibitor. A new feasible scheme is provided for early diagnosis, treatment, curative effect evaluation and the like of tumors.

Compounds for treating central nervous system degenerative diseases or brain tumor and application thereof

The invention relates to compounds and a medicine composition for treating central nervous system degenerative diseases or brain tumor and application thereof. The compounds have the structure of the formula (see the formula in the description) and can se

Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes

The profiling of kinases using established proteomics techniques is hampered by their non-covalent mode-of-action. One way to overcome this caveat is the use of probes featuring photo-labelling groups that can be activated by UV irradiation to generate a reactive species that will establish a covalent bond to the enzyme. In this study we have used the well-known kinase inhibitor H89 as a lead for the development of probes for the affinity-based profiling of clinically relevant kinases. A labelling protocol was established for recombinant kinases and more complex protein mixtures using gel-based techniques. We also show that the probes act in a competitive manner with other kinase inhibitors.