844821-65-4Relevant articles and documents
A new synthesis of difluoromethanesulfonamides - A novel pharmacophore for carbonic anhydrase inhibition
Boyle, Nicholas A.,Chegwidden, W. Richard,Blackburn, G. Michael
, p. 222 - 224 (2007/10/03)
Preparation of the key intermediate carboxydifluoromethanesulfonamide provides direct synthetic access to a wide range of novel difluoromethanesulfonamides, including the acetazolamide analogue (2-ethanoylamino-1,3,4-thiadiazol-5-yl)-difluoromethanesulfonamide. Their water solubility and stability, ether partition coefficient, pK, and submicromolar dissociation constants for human carbonic anhydrase isozyme II (HCA II) make them promising candidates for topical glaucoma therapy.
