84487-15-0

Basic information

• Product Name: 2-BROMO-5-NITROPYRIDIN-4-AMINE
• Synonyms: 2-BROMO-5-NITROPYRIDIN-4-AMINE;4-Amino-2-bromo-5-nitropyridine;2-BroMo-5-nitro-4-pyridinaMine;4-AMino-2-broMo-5-nitropy...;(2-Bromo-5-nitropyridin-4-yl)amine;2-broMo-5-nitropyridin-4-aMino
• CAS NO: 84487-15-0
• Molecular Formula: C₅H₄BrN₃O₂
• Molecular Weight: 218.02
• Mol File: 84487-15-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 396.3 °C at 760 mmHg
• Flash Point: 193.5 °C
• Appearance: /
• Density: 1.929±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.72E-06mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.79±0.42(Predicted)
• CAS DataBase Reference: 2-BROMO-5-NITROPYRIDIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-NITROPYRIDIN-4-AMINE(84487-15-0)
• EPA Substance Registry System: 2-BROMO-5-NITROPYRIDIN-4-AMINE(84487-15-0)

Safety Data

• Hazardous Substances Data: 84487-15-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-nitropyridin-4-amine is a chemical compound with the molecular formula C5H4BrN3O2. It is a derivative of pyridine and contains a bromine atom, a nitro group, and an amino group attached to the pyridine ring. 2-Bromo-5-nitropyridin-4-amine is commonly used in organic synthesis for the preparation of various pharmaceuticals, agrochemicals, and dyes. It has also been studied for its potential biological activities, including its anti-cancer and anti-inflammatory properties. Additionally, 2-Bromo-5-nitropyridin-4-amine is an important building block in the synthesis of various heterocyclic compounds used in medicinal and agricultural chemistry. Due to its therapeutic potential and versatile synthetic applications, this compound is of considerable interest to researchers in the field of organic chemistry.

InChI:InChI=1/C5H4BrN3O2/c6-5-1-3(7)4(2-8-5)9(10)11/h1-2H,(H2,7,8)

Upstream product

• 4487-57-4 2,4-dibromo-5-nitropyridine 
• 31872-62-5 4-methoxy-3-nitro-pyridine 
• 607373-82-0 2-hydroxy-4-methoxy-5-nitro pyridine 

Downstream Products

• 850663-98-8 methyl 3-[(4-amino-5-nitro-2-pyridinyl)oxy]benzoate 
• 850663-97-7 methyl 3-{[2-(4-amino-furazan-3-yl)-1H-imidazo[4,5-c]pyridin-6-yl]oxy}benzoate 
• 850664-00-5 methyl 3-[(4,5-diamino-2-pyridinyl)oxy]benzoate 
• 1033203-41-6 6-bromopyridine-3,4-diamine 
• 1332875-94-1 2-(3-tert-butyl-isoxazol-5-yl)-4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine 
• 1332875-76-9 3-tert-Butyl-5-[4-chloro-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1-methyl-1H-pyrazole-4-carbonitrile 
• 1332875-75-8 2-chloro-6-(2-trifluoromethyl-phenyl)-pyridine-3,4-diamine 
• 1332875-74-7 5-nitro-2-(2-trifluoromethyl-phenyl)-pyridin-4-ylamine 

Relevant articles and documents

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics

Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

Structure-based drug design of novel, potent, and selective azabenzimidazoles (ABI) as ATR inhibitors

Compound 13 was discovered through morphing of the ATR biochemical HTS hit 1. The ABI series was potent and selective for ATR. Incorporation of a 6-azaindole afforded a marked increase in cellular potency but was associated with poor PK and hERG ion channel inhibition. DMPK experiments established that CYP P450 and AO metabolism in conjunction with Pgp and BCRP efflux were major causative mechanisms for the observed PK. The series also harbored the CYP3A4 TDI liability driven by the presence of both a morpholine and an indole moiety. Incorporation of an adjacent fluorine or nitrogen into the 6-azaindole addressed many of the various medicinal chemistry issues encountered. (Chemical Presented).