844870-83-3

Basic information

• Product Name: 6-Chloro-2-((1-(2,2-difluoroethyl)-5-(methylsulfonyl)-1H-pyrazol-3-yl)methyl)-4-phenyl-3-propionylisoquinolin-1(2H)-one
• CAS NO: 844870-83-3
• Molecular Formula: C25H22ClF2N3O4S
• Molecular Weight: 533.9746864
• Mol File: 844870-83-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-Chloro-2-((1-(2,2-difluoroethyl)-5-(methylsulfonyl)-1H-pyrazol-3-yl)methyl)-4-phenyl-3-propionylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-2-((1-(2,2-difluoroethyl)-5-(methylsulfonyl)-1H-pyrazol-3-yl)methyl)-4-phenyl-3-propionylisoquinolin-1(2H)-one(844870-83-3)
• EPA Substance Registry System: 6-Chloro-2-((1-(2,2-difluoroethyl)-5-(methylsulfonyl)-1H-pyrazol-3-yl)methyl)-4-phenyl-3-propionylisoquinolin-1(2H)-one(844870-83-3)

Safety Data

• Hazardous Substances Data: 844870-83-3(Hazardous Substances Data)

Upstream product

• 844870-71-9 6-chloro-2-{[5-(methylsulfonyl)-1H-pyrazol-3-yl]methyl}-4-phenyl-3-propionylisoquinolin-1(2H)-one 
• 359-13-7 difluoroethanol 

Relevant articles and documents

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2)

3-Metoxycarbonyl isoquinolone derivative 1 has been identified as a potent JNK inhibitor and significantly inhibited cardiac hypertrophy in a rat pressure-overload model. Herein, a series of isoquinolones with an imidazolylmethyl or a pyrazolylmethyl group at the 2-position were designed based on X-ray crystallographic analysis of the complex between the isoquinolone compound and JNK3, as wells as the relationship between compound lipophilicity (log D) and activity in a cell-based assay. The compounds prepared showed potent JNK1 inhibitory activities in a cell-based assay. Among them the isoquinolone derivative possessing 5-[(cyclopropylamino)carbonyl]-1-methyl-1H-pyrazole (16e) exhibited significant anti-hypertrophic activity at doses of more than 1 mg/kg (po) in a pressure-overload model.