84499-72-9 Usage
Description
(S)-1-(p-Tolyl)ethanaMine hydrochloride is a white crystalline powder that is soluble in water and has a molecular weight of 185.67 g/mol. It is a chemical compound commonly used as a reagent in organic synthesis and is known for its versatility and importance in the field of organic chemistry.
Uses
Used in Pharmaceutical Industry:
(S)-1-(p-Tolyl)ethanaMine hydrochloride is used as a reagent for the production of various drugs and medications, contributing to the development of new pharmaceuticals and improving existing ones.
Used as a Chiral Auxiliary:
In the field of asymmetric synthesis, (S)-1-(p-Tolyl)ethanaMine hydrochloride is used as a chiral auxiliary, which helps in the selective formation of enantiomers, an essential aspect in the synthesis of biologically active compounds.
Used as a Ligand in Coordination Chemistry:
(S)-1-(p-Tolyl)ethanaMine hydrochloride serves as a ligand in coordination chemistry, playing a crucial role in the formation and stabilization of metal complexes, which have applications in various areas such as catalysis and materials science.
Used in Polymer Development:
(S)-1-(p-Tolyl)ethanaMine hydrochloride is also utilized in the development of polymers and other organic materials, where it can influence the properties and performance of the resulting polymers, making them suitable for specific applications.
Check Digit Verification of cas no
The CAS Registry Mumber 84499-72-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,4,9 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 84499-72:
(7*8)+(6*4)+(5*4)+(4*9)+(3*9)+(2*7)+(1*2)=179
179 % 10 = 9
So 84499-72-9 is a valid CAS Registry Number.
84499-72-9Relevant articles and documents
Synthesis method of primary amine hydrochloride
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Paragraph 0034-0037, (2019/03/09)
The invention discloses a synthesis method of primary amine hydrochloride. According to the synthesis method, in the presence of a gold complex, water and alkyne carry out catalytic hydrolysis to generate ketones, and then ketones and ammonium formate are catalyzed by a rhodium complex to generate primary amine. Compared with a conventional primary amine synthesis method, the synthesis method hasthe advantages that no alkali is added during the reaction process, no side product is generated, the atomic economy is good, the reaction conditions are mild, and the synthesis method has a wide prospect.
Rhodium-catalyzed asymmetric hydrogenation of unprotected NH imines assisted by a thiourea
Zhao, Qingyang,Wen, Jialin,Tan, Renchang,Huang, Kexuan,Metola, Pedro,Wang, Rui,Anslyn, Eric V.,Zhang, Xumu
supporting information, p. 8467 - 8470 (2014/08/18)
Asymmetric hydrogenation of unprotected NH imines catalyzed by rhodium/bis(phosphine)-thiourea provided chiral amines with up to 97% yield and 95% ee. 1HNMR studies, coupled with control experiments, implied that catalytic chloride-bound intermediates were involved in the mechanism through a dual hydrogen-bonding interaction. Deuteration experiments proved that the hydrogenation proceeded through a pathway consistent with an imine.
