84501-64-4

Basic information

• Product Name: PIPERAZINE-2-CARBOXAMIDE
• Synonyms: (+/-)-PIPERAZINE-2-AMIDE;PIPERAZINE-2-CARBOXAMIDE;2-Piperazinecarboxamide(6CI,9CI);(+/-)-Piperazin-2-amide;2-Carbamoylpiperazine
• CAS NO: 84501-64-4
• Molecular Formula: C₅H₁₁N₃O
• Molecular Weight: 129.16
• EINECS: 282-984-3
• Product Categories: AMIDE;pharmacetical;Pyrans, Piperidines & Piperazines
• Mol File: 84501-64-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 144-145 °C(Solv: ethanol (64-17-5))
• Boiling Point: 364.2 °C at 760 mmHg
• Flash Point: 174 °C
• Appearance: /
• Density: 1.104 g/cm³
• Vapor Pressure: 1.72E-05mmHg at 25°C
• Refractive Index: 1.48
• Storage Temp.: 2-8°C
• PKA: 16.52±0.20(Predicted)
• CAS DataBase Reference: PIPERAZINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERAZINE-2-CARBOXAMIDE(84501-64-4)
• EPA Substance Registry System: PIPERAZINE-2-CARBOXAMIDE(84501-64-4)

Safety Data

• Hazardous Substances Data: 84501-64-4(Hazardous Substances Data)

Usage

General Description

PIPERAZINE-2-CARBOXAMIDE, also known as piperazine amide, is a chemical compound with the molecular formula C6H10N4O. It is a white crystalline powder that is soluble in water and alcohol. PIPERAZINE-2-CARBOXAMIDE is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs, including antihistamines, antipsychotics, and antimalarial agents. It acts as a building block in the production of these medications, contributing to their therapeutic effects. Additionally, PIPERAZINE-2-CARBOXAMIDE is used in the research and development of new pharmaceutical compounds due to its versatile properties and reactivity.

InChI:InChI=1/C5H11N3O/c6-5(9)4-3-7-1-2-8-4/h4,7-8H,1-3H2,(H2,6,9)

Upstream product

• 188847-59-8 1,4-dibenzyl-piperazine-2-carboxylic acid amide 
• 98-96-4 pyrazinamide 

Downstream Products

• 83898-63-9 hexahydro-3,3-dimethylimidazo[1,5-a]pyrazin-1(5H)-one 
• 112257-24-6 tert-butyl 3-(aminocarbonyl)piperazine-1-carboxylate 
• 100828-16-8 4-(3-phosphonopropyl)-2-piperazinecarboxylic acid 
• 147650-70-2 (2S)-piperazine-2-carboxylic acid 
• 31321-68-3 (R)-piperazine-2-carboxylic acid 

Relevant articles and documents

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Here we describe the use of a new open-source software package and a Raspberry Pi computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater, used in the treatment of tuberculosis - and its reduced derivative piperazine-2- carboxamide.

Piperazine additions to C60 - A facile approach to fullerene substitution

A range of fullerene monoadducts can be generated via the photochemical reaction of piperazine derivatives with C60. Addend functionality can also be efficiently incorporated by transformation of the hydroxyl-substituted adduct prepared in this fashion. Reaction yields and process simplicity compete with current standard procedures for fullerene mono-functionalisation. The Royal Society of Chemistry 2005.

Method of preventing or limiting reperfusion damage

There is disclosed a process for preparing (l)-(-)-2-aminocarbonyl)-N-(4-amino-2,6-dichlorophenyl)-4-?5,5-bis(4-fluorophenyl)pentyl!-1-piperazineacetamide which comprises the steps of (a) cyclizing (-)-(S,S)-N1,N2 -bis(1-phenylethyl)-1,2-ethanediamine with 2,3-dibromopropanamide in a reaction-inert solvent in the presence of a base, thus yielding an intermediate; (b) resolving the intermediate of into two stereoisomers and recovering thereby ?1(S),2A,4(S)!-1,4-bis(1-phenylethyl)-2-piperazinecarboxamide; (c) hydrogenolyzing ?1(S),2A,4(S)!-1,4-bis(1-phenylethyl)-2-piperazinecarboxamide under a hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce (+) -2-piperazinecarboxamide; (d) reductively N-alkylating (+)-2-piperazinecarboxamide with 5,5-bis(4-fluorophenyl)pentaldehyde under a hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce a compound of the formula: STR1 (e) N-alkylating the compound of Formula (VII) with an alkylating reagent of the formula: STR2 wherein W represents a reactive leaving group, in a reaction-inert solvent in the presence of a base to form the nitro analog of the desired compound; and (f) reducing the nitro compound in the presence of a reducing agent in a reaction-inert solvent.