84504-69-8 Usage
Description
Irsogladine maleate is a gastroprotective agent that enhances gap junction intercellular communication (GJIC) and exhibits anti-ulcer properties. It is a selective phosphodiesterase 4 (PDE4) inhibitor that modulates cellular processes and has been shown to inhibit gastric mucosal lesion formation and superoxide anion production.
Used in Pharmaceutical Industry:
Irsogladine maleate is used as an anti-ulcer drug for its ability to inhibit gastric mucosal lesion formation and decrease in gastric mucosal blood flow, providing gastroprotection and promoting healing of ulcers.
Irsogladine maleate is used as a selective PDE4 inhibitor for its role in modulating cellular processes, which can be beneficial in treating various gastrointestinal disorders and inflammatory conditions.
Irsogladine maleate is used to enhance gap junction intercellular communication (GJIC) for improving cellular interactions and contributing to the overall health and function of the gastrointestinal tract.
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Check Digit Verification of cas no
The CAS Registry Mumber 84504-69-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,5,0 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 84504-69:
(7*8)+(6*4)+(5*5)+(4*0)+(3*4)+(2*6)+(1*9)=138
138 % 10 = 8
So 84504-69-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-
84504-69-8Relevant articles and documents
Irsogladine maleate preparation method
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Paragraph 0009; 0010, (2019/05/16)
The invention belongs to the field of organic matter synthesis, and particularly relates to an irsogladine maleate preparation method, wherein p-dichlorobenzene is used as a starting raw material, andfive reactions of acetylation, bromoform reaction, cyanation, cyclization and salt formation are performed to prepare the target compound. According to the present invention, the new irsogladine maleate preparation method is used, can significantly accelerate the reaction rate and improve the yield, has advantages of cost reducing, environment protection, simple operation and convenient post-treatment, and is suitable for industrial production.