84507-68-6

Basic information

• Product Name: 20-hydroxyecdysone 20,22-acetonide
• CAS NO: 84507-68-6
• Molecular Weight: 520.707
• Mol File: 84507-68-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 20-hydroxyecdysone 20,22-acetonide(CAS DataBase Reference)
• NIST Chemistry Reference: 20-hydroxyecdysone 20,22-acetonide(84507-68-6)
• EPA Substance Registry System: 20-hydroxyecdysone 20,22-acetonide(84507-68-6)

Safety Data

• Hazardous Substances Data: 84507-68-6(Hazardous Substances Data)

Upstream product

• 5289-74-7 20-Hydroxyecdysone 
• 67-64-1 acetone 
• 77-76-9 2,2-dimethoxy-propane 
• 1135990-12-3 2-dehydro-3-epi-20-hydroxyecdysone acetonide 
• 698975-65-4 20-hydroxyecdysone 20,22-acetonide 2,3-dimesylate 
• 84507-66-4 20-hydroxyecdysone 2,3:20,22-diacetonide 
• 698975-66-5 2,3-didehydro-2,3-dideoxy-20-hydroxyecdysone 20,22-acetonide 
• 22798-98-7 20-hydroxyecdysone-2,3:20,22-diacetonide 

Downstream Products

• 5289-74-7 20-Hydroxyecdysone 
• 1253967-65-5 2,3-O-[2-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)ethylidene]-20,22-O-isopropylidenestachysterone 
• 1253967-63-3 2,3-O-[2-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)ethylidene]-20,22-O-isopropylidene-20-hydroxyecdysone 
• 22785-88-2 2-deoxyecdysterone 
• 5289-74-7 20-hydroxyecdysone 
• 30655-79-9 14-dehydro-20-hydroxyecdysone 

Relevant articles and documents

Stereoselective synthesis and moulting activity of 2,3-diepi-20- hydroxyecdysone and 2,3-diepi-5α-20-hydroxyecdysone

The ecdysteroid analogues 2,3-diepi-20-hydroxyecdysone and 2,3-diepi-5α-20-hydroxyecdysone have been synthesized from the readily available ecdysteroid, 20-hydroxyecdysone, and moulting activity has been determined using the Musca bioassay. As expected, the 2,3-diepi-analogue was less active than the parent ecdysteroid, 20-hydroxyecdysone. However, the 2,3-diepi-5α-analogue, which was expected to be inactive in the assay, exhibited moulting activity though it was approximately 1.5-fold less active than its 5β-analogue. The activity of the 5α-analogue could possibly result from the ability of this compound to bind to the ecdysteroid receptor. Alternatively, a possible in vivo C-5 epimerization of the 2,3-diepi-5α- analogue to the corresponding 5β-analogue could account for its activity.

Steroidal ligands and their use in gene switch modulation

The present invention relates to steroidal ligands for use in nuclear receptor-based inducible gene expression systems. The invention further relates to methods of modulating the expression of genes of interest with a system containing one or more nuclear

Synthesis and structure-activity relationships of novel ecdysteroid dioxolanes as MDR modulators in cancer

Ecdysteroids, molting hormones of insects, can exert several mild, non-hormonal bioactivities in mammals, including humans. In a previous study, we have found a significant effect of certain derivatives on the ABCB1 transporter mediated multi-drug resistance of a transfected murine leukemia cell line. In this paper, we present a structure-activity relationship study focused on the apolar dioxolane derivatives of 20-hydroxyecdysone. Semi-synthesis and bioactivity of a total of 32 ecdysteroids, including 20 new compounds, is presented, supplemented with their complete 1H- and 13C-NMR signal assignment.