84546-74-7

Basic information

• Product Name: 2(1H)-Quinoxalinone, 3-methyl-1-(phenylmethyl)-
• CAS NO: 84546-74-7
• Molecular Formula: C16H14N2O
• Molecular Weight: 250.3
• Mol File: 84546-74-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinoxalinone, 3-methyl-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone, 3-methyl-1-(phenylmethyl)-(84546-74-7)
• EPA Substance Registry System: 2(1H)-Quinoxalinone, 3-methyl-1-(phenylmethyl)-(84546-74-7)

Safety Data

• Hazardous Substances Data: 84546-74-7(Hazardous Substances Data)

Upstream product

• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 
• 100-39-0 benzyl bromide 
• 98-88-4 benzoyl chloride 
• 95-54-5 1,2-diamino-benzene 
• 1239573-84-2 C₁₆H₁₅BrINO 
• 5822-13-9 N-benzyl-1,2-phenylenediamine 
• 127-17-3 2-oxo-propionic acid 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 63536-44-7 1-benzyl-1,2-dihydroquinoxalin-2-one 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 1774-47-6 trimethylsulfoxonium iodide 
• 1196-57-2 quinoxalin-2⁽¹⁾-one 
• 75-91-2 tert.-butylhydroperoxide 
• 3240-34-4 [bis(acetoxy)iodo]benzene 

Downstream Products

• 328249-83-8 1-benzyl-3-bromomethyl-1H-quinoxalin-2-one 

Relevant articles and documents

Alkylation of quinoxalin-2(1H)-ones using phosphonium ylides as alkylating reagents

A practical and efficient methodology for the construction of 3-alkylquinoxalinones through base promoted direct alkylation of quinoxalin-2(1H)-ones with phosphonium ylides as alkylating reagents under metal- and oxidant-free conditions was developed. Various 3-alkylquinoxalin-2(1H)-ones were easily obtained in good to excellent yields. Tentative mechanistic studies suggest that this reaction is likely to involve a nucleophilic addition-elimination process.

C?H Methylation of Iminoamido Heterocycles with Sulfur Ylides**

The direct methylation of N-heterocycles is an important transformation for the advancement of pharmaceuticals, agrochemicals, functional materials, and other chemical entities. Herein, the unprecedented C(sp2)-H methylation of iminoamido heterocycles as nucleoside base analogues is described. Notably, trimethylsulfoxonium salt was employed as a methylating agent under aqueous conditions. A wide substrate scope and excellent level of functional-group tolerance were attained. Moreover, this method can be readily applied to the site-selective methylation of azauracil nucleosides. The feasibility of gram-scale reactions and various transformations of the products highlight the synthetic potential of the developed method. Combined deuterium-labeling experiments aided the elucidation of a plausible reaction mechanism.

Preparation method of 3-methylquinoxaline-2-(1H)-one derivative

The invention discloses a preparation method of a 3-methylquinoxaline-2-(1H)-one derivative. The preparation method comprises the following steps: by taking elemental iodine as an oxidizing agent, sodium sulfite as an additive and tert-butyl hydroperoxide (TBHP) as a methyl source, carrying out a direct methylation reaction on carbon No. 3 on a quinoxaline-2-(1H)-one compound in an organic solvent, and after the reaction is completed, carrying out aftertreatment to obtain the 3-methylquinoxaline-2-(1H)-one derivative. The preparation method uses cheap and easily available reaction raw materials and is simple.