84547-59-1

Basic information

• Product Name: 1-Methyl-1H-pyrazole-5-carbonyl chloride
• Synonyms: 1-Methyl-1H-pyrazole-5-carbonyl chloride;1H-Pyrazole-5-carbonyl chloride, 1-methyl- (9CI);1-Methyl-1H-pyrazole-5-carbonyl chloride 97%;1H-pyrazole-5-carbonyl chloride, 1-methyl-;2-Methyl-2H-pyrazole-3-carbonyl chloride, 5-(Chlorocarbonyl)-1-methyl-1H-pyrazole;2-methyl-3-pyrazolecarbonyl chloride;2-methylpyrazole-3-carbonyl chloride
• CAS NO: 84547-59-1
• Molecular Formula: C₅H₅ClN₂O
• Molecular Weight: 144.559
• Product Categories: ACIDHALIDE
• Mol File: 84547-59-1.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 226.6 °C at 760 mmHg
• Flash Point: 90.8 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0.0813mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 1-Methyl-1H-pyrazole-5-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-pyrazole-5-carbonyl chloride(84547-59-1)
• EPA Substance Registry System: 1-Methyl-1H-pyrazole-5-carbonyl chloride(84547-59-1)

Safety Data

• Hazard Codes: C
• HazardClass: IRRITANT
• Hazardous Substances Data: 84547-59-1(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-pyrazole-5-carbonyl chloride is a chemical compound with the molecular formula C6H6ClN. It is an acyl chloride derivative of 1-methyl-1H-pyrazole-5-carboxylic acid and is often used as a building block in the synthesis of various organic compounds. 1-Methyl-1H-pyrazole-5-carbonyl chloride has been investigated for its potential applications in the pharmaceutical industry, particularly in the development of new drugs and pharmaceutical intermediates. It is a versatile reagent that can be used in a variety of chemical reactions, making it a valuable tool for organic chemists and researchers in the field of medicinal chemistry. Additionally, it is important to handle this compound with caution, as it is a hazardous material that should be handled and used in accordance with proper safety protocols and guidelines.

InChI:InChI=1/C5H5ClN2O/c1-8-4(5(6)9)2-3-7-8/h2-3H,1H3

Upstream product

• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 7719-09-7 thionyl chloride 

Downstream Products

• 1092391-89-3 N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-1-methyl-1H-pyrazole-5-carboxamide 
• 1079400-14-8 N-(6-amino-5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxamide 
• 1079400-13-7 N-(6-amino-5-(2-chloro-4-fluorophenyl)pyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxamide 
• 1079400-05-7 N-(6-amino-5-(2,3,5-trichlorophenyl)pyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxamide 
• 1079399-99-7 N-(6-amino-5-(2-chlorophenyl)pyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxamide 
• 1079400-03-5 N-(6-amino-5-(2,5-dichlorophenyl)pyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxamide 
• 1079400-07-9 N-(6-amino-5-(2-chloro-5-methoxyphenyl)pyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxamide 
• 1005610-37-6 4-iodo-1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-pyrazole-5-carboxamide 
• 1446442-92-7 1-methyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1H-pyrazole-5-carboxamide 
• 1318754-71-0 1-methyl-N-{4-(trifluoromethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1H-pyrazole-5-carboxamide 
• 1318754-59-4 ethyl 5-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-2-[3-(trifluoromethyl)benzyl]-1,3-thiazole-4-carboxylate 
• 1318754-66-3 N-{4-ethenyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide 
• 1318754-64-1 1-methyl-N-{4-(1-methylethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1H-pyrazole-5-carboxamide 
• 1318754-63-0 N-{4-(1-hydroxy-1-methylethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide 

Relevant articles and documents

FUSED AZOLE HETEROCYCLES AS AHR ANTAGONISTS

The present disclosure relates to thiazolo-pyridine, oxazolo-pyridine, pyrrolo-pyridine, pyrrolo-pyrazine and pyrrolo-pyrimidine compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing

Vinylogous Elimination/C-H Functionalization/Allylation Cascade Reaction of Allenoate Adducts: Synthesis of Ring-Fused Dihydropyridinones

A palladium-catalyzed cascade reaction of β′-allenoate adducts with aryl/heteroaryl carboxamides through a vinylogous elimination/C-H functionalization/intramolecular allylation reaction sequence has been developed with high Z stereoselectivity. Various ring-fused dihydropyridinones bearing an α,β-unsaturated ester substituent are obtained. It is the first example of application of the allenoate adducts to C-H functionalization annulations as practical precursors of hard-to-get functionalized electron-deficient 1,3-butadienes. Using air as the terminal oxidant also shows a great advantage in environmental friendliness.

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

Voltage-gated sodium channels, in particular Nav1.8, can be targeted for the treatment of neuropathic and inflammatory pain. Herein, we described the optimization of Nav1.8 modulator series to deliver subtype selective, state, and use-dependent chemical matter that is efficacious in preclinical models of neuropathic and inflammatory pain. (Chemical Presented).