84547-64-8

Basic information

• Product Name: 3-(Chloromethyl)-1-methyl-1H-pyrazole
• Synonyms: 3-(CHLOROMETHYL)-1-METHYL-1H-PYRAZOLE;3-(Chloromethyl)-1-methyl-1H-pyrazole 97%;3-(Chloromethyl)-1-methyl-1H-pyrazole dihydrochloride;3-(Chloromethyl)-1-methyl-1H-pyrazole hydrochloride;(ChloroMethyl)-1-Methyl-1H-pyrazole;3-(Chloromethyl)-1-methyl-1H-pyrazole97%;3-Chloromethyl-1-methylpyrazole
• CAS NO: 84547-64-8
• Molecular Formula: C5H7ClN2
• Molecular Weight: 130.57548
• Mol File: 84547-64-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 215.2 °C at 760 mmHg
• Flash Point: 84 °C
• Appearance: /
• Density: 1.2
• Vapor Pressure: 0.219mmHg at 25°C
• Refractive Index: 1.55
• PKA: 1.31±0.10(Predicted)
• CAS DataBase Reference: 3-(Chloromethyl)-1-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Chloromethyl)-1-methyl-1H-pyrazole(84547-64-8)
• EPA Substance Registry System: 3-(Chloromethyl)-1-methyl-1H-pyrazole(84547-64-8)

Safety Data

• Hazard Codes: C
• RIDADR: UN3265
• Hazardous Substances Data: 84547-64-8(Hazardous Substances Data)

Usage

General Description

3-(Chloromethyl)-1-methyl-1H-pyrazole is a chemical compound with the molecular formula C6H8ClN3. It is a pyrazole derivative that contains a chloromethyl group and a methyl group attached to the pyrazole ring. 3-(Chloromethyl)-1-methyl-1H-pyrazole is often used in organic synthesis as a building block for the preparation of various heterocyclic compounds. It is also used in the production of pharmaceutical drugs and agrochemicals. However, it is important to handle this compound with caution as it is considered to be a potential irritant and harmful if ingested or inhaled.

InChI:InChI=1/C5H7ClN2/c1-8-3-2-5(4-6)7-8/h2-3H,4H2,1H3

Upstream product

• 15787-79-8 chloromethyl β-chlorovinyl ketone 
• 57-14-7 N,N-Dimethylhydrazine 
• 17827-61-1 methyl ester of 1-methylpyrazole-3-carboxylic acid 
• 84547-62-6 (1-methyl-1H-pyrazol-3-yl)methanol 

Downstream Products

• 1607023-04-0 5-(4-chloro-3-methoxyphenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-49-3 5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 

Relevant articles and documents

5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER

The invention is directed to substituted 5-(1H-benzo[d]imidazo-2-yl)- pyridin-2-amine and 5-(3H-imidazo[4,5-b]pyridin-6-yl)-pyridin-2-amine derivatives. Specifically, the invention is directed to compounds according to Formula (lb) wherein R', R2', R3', R4', Rs', R6', R7', and X1' are as defined herein; or a salt thereof including a pharmaceutically acceptable salt thereof. The compounds of the invention decrease MYC protein (c-MYC) in cells and/or inhibit p300/CBP histone acetyltransferase and can be useful in the treatment of cardiac hypertrophy, diabetes, obesity and nonalcoholic fatty liver disease, HIV, polycystic kidney disease, inflammatory diseases, ankylosing spondylitis, psoriasis, psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, cancer and pre-cancerous syndromes, and diseases associated with dysregulation of Myc or inhibition of p300/CBP histone acetyltransferase. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention still further discloses methods of reducing MYC protein (c-MYC) in cells and inhibiting p300/CBP histone acetyltransferase activity, and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS

The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.

New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-(5-halo)pyrazoles from chloro(bromo) vinyl ketones and N,N-dimethylhydrazine

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro-(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl(5-halo)pyrazoles. The reaction is accompanied by elimination of methyl halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.