845866-86-6

Basic information

• Product Name: 5-TERT-BUTYL-2-(2-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE
• Synonyms: BUTTPARK 74\09-02;3-TERT-BUTYL-1-(2-FLUOROPHENYL)-1H-PYRAZOL-5-AMINE;5-TERT-BUTYL-2-(2-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE;1H-Pyrazol-5-aMine,3-(1,1-diMethylethyl)-1-(2-fluorophenyl)-
• CAS NO: 845866-86-6
• Molecular Formula: C13H16FN3
• Molecular Weight: 233.28
• Mol File: 845866-86-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-TERT-BUTYL-2-(2-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-TERT-BUTYL-2-(2-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE(845866-86-6)
• EPA Substance Registry System: 5-TERT-BUTYL-2-(2-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE(845866-86-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 845866-86-6(Hazardous Substances Data)

Usage

Description

5-TERT-BUTYL-2-(2-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE is a pyrazole derivative that features a tert-butyl-substituted amine and a 2-fluoro-phenyl group attached to a pyrazole ring. This chemical compound is recognized for its potential in pharmaceutical research and development, as well as its utility in material science. Its unique structure and properties position it as a valuable component in the synthesis of complex organic compounds.

Uses

Used in Pharmaceutical Research:
5-TERT-BUTYL-2-(2-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE is used as a key intermediate in the synthesis of new drugs, particularly for the development of pharmaceuticals that target specific biological pathways or diseases.
Used in Material Science:
In the field of material science, 5-TERT-BUTYL-2-(2-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE is utilized as a building block for creating novel materials with unique properties, such as improved stability or reactivity.
Used in Organic Synthesis:
5-TERT-BUTYL-2-(2-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE is used as a versatile reagent in organic synthesis, enabling the creation of a wide range of complex organic compounds for various applications, including pharmaceuticals, agrochemicals, and specialty chemicals.

Upstream product

• 59997-51-2 trimethylacetylacetonitrile 
• 2368-80-1 2-fluorophenylhydrazine 

Relevant articles and documents

Biophysical investigation and conformational analysis of p38α kinase inhibitor doramapimod and its analogues

Doramapimod (BIRB 796) is a potent inhibitor of p38α mitogen-activated protein kinase. It contains an aryl-pyrazole scaffold as a pharmacophore critical for binding. The aryl-pyrazole scaffold is not planar and adopts an out-of-plane conformation, which is described by the torsion angle θ. In this letter, we report the chemical synthesis and biophysical characterization of different analogues of doramapimod (3-12) exhibiting distinctly different aryl-pyrazole torsion angle θ values. The torsion angle θ values of the synthesized analogues (3-6) were determined by crystal structural analysis and the binding affinities to p38α kinase investigated by microscale thermophoresis. Our results unveil a clear correlation between kinase binding and the torsion angle θ of tested doramapimod analogues, highlighting the importance of inhibitor conformation for protein binding.