84589-39-9Relevant articles and documents
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class i Histone Deacetylase Inhibitor Largazole
Clausen, Dane J.,Smith, William B.,Haines, Brandon E.,Wiest, Olaf,Bradner, James E.,Williams, Robert M.
, p. 5061 - 5074 (2015/08/03)
The formation of a series of analogs containing a pyridine moiety in place of the natural thiazole heterocycle, based on the potent, naturally occurring HDAC inhibitor Largazole has been accomplished. The synthetic strategy was designed modularly to access multiple inhibitors with different aryl functionalities containing both the natural depsipeptide and peptide isostere variant of the macrocycle. The cytotoxicity and biochemical activity of the library of HDAC inhibitors is described herein.
Radiation-induced Alkylation, Hydroxyalkylation, and Reduction of Pyridinecarboxamides in Acidic Alcoholic Solutions
Sugimori, Akira,Nishijima, Masayuki,Itoh, Hiroshi
, p. 3055 - 3056 (2007/10/02)
The γ-irradiation of pyridinecarboxamides in acidic methanol or ethanol brings about substitution of the ring hydrogen by alkyl or hydroxyalkyl groups derived from the solvent alcohols in relatively high G-values.In 2-propanol, little alkylation and hydroxyalkylation occur and reduction of CONH2 to CH2OH occurs in low G-values.
