846023-24-3

Basic information

• Product Name: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
• Synonyms: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE;AcetaMide,2-cyano-N-(2,4-dichloro-5-Methoxyphenyl)-
• CAS NO: 846023-24-3
• Molecular Formula: C₁₀H₈Cl₂N₂O₂
• Molecular Weight: 259.09
• Mol File: 846023-24-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 180-181 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 462.4 °C at 760 mmHg
• Flash Point: 233.4 °C
• Appearance: /
• Density: 1.436 g/cm³
• Vapor Pressure: 9.92E-09mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.71±0.10(Predicted)
• CAS DataBase Reference: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE(846023-24-3)
• EPA Substance Registry System: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE(846023-24-3)

Safety Data

• Hazardous Substances Data: 846023-24-3(Hazardous Substances Data)

Usage

Description

2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE, with the CAS number 846023-24-3, is a pale yellow powder that serves as a useful research chemical. Its chemical structure features a cyano group, a dichloro-methoxyphenyl group, and an amide linkage, which may contribute to its potential applications in various fields.

Uses

Used in Research and Development:
2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE is used as a research chemical for exploring its properties and potential applications in different industries. Its unique chemical structure may offer opportunities for the development of new compounds and materials with specific functions and characteristics.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE may be used as an intermediate or building block in the synthesis of new drugs or drug candidates. Its chemical properties could be harnessed to create molecules with therapeutic potential, targeting various diseases and conditions.
Used in Chemical Synthesis:
2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE can be used as a reagent or precursor in chemical synthesis processes. Its functional groups may participate in various chemical reactions, enabling the production of a range of compounds with diverse applications.
Used in Material Science:
In the field of material science, 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE may be utilized in the development of new materials with specific properties. Its incorporation into polymers, coatings, or other materials could lead to the creation of innovative products with enhanced performance characteristics.

InChI:InChI=1/C10H8Cl2N2O2/c1-16-9-5-8(6(11)4-7(9)12)14-10(15)2-3-13/h4-5H,2H2,1H3,(H,14,15)

Upstream product

• 98446-49-2 2,4-dichloro-5-methoxyaniline 
• 372-09-8 cyanoacetic acid 
• 538-75-0 dicyclohexyl-carbodiimide 
• 591-27-5 m-Hydroxyaniline 
• 67669-19-6 N-(2,4-dichloro-5-hydroxyphenyl)acetamide 

Downstream Products

• 380843-75-4 bosutinib 
• 1334310-24-5 C₂₇H₂₇Cl₂N₇O₂ 
• 1334396-28-9 C₃₁H₃₃Cl₂N₇O₂ 
• 1334311-15-7 C₃₀H₃₁Cl₂N₇O₂ 
• 1334311-68-0 C₂₈H₂₇Cl₂N₇O₂ 
• 1334310-23-4 C₂₉H₃₁Cl₂N₇O₂ 
• 1334396-27-8 C₂₈H₂₉Cl₂N₇O₂ 
• 1334309-46-4 C₂₇H₂₈Cl₂N₈O₂ 
• 1334310-95-0 C₂₆H₂₅Cl₂N₇O₂ 
• 1334310-22-3 C₂₉H₂₉Cl₂N₇O₂ 
• 1334312-08-1 C₂₈H₂₇Cl₂N₇O₂ 
• 1334310-77-8 C₂₈H₂₉Cl₂N₇O₂ 
• 1334309-74-8 C₂₇H₂₇Cl₂N₇O₂ 
• 1334396-29-0 C₂₀H₁₃Cl₂N₃O₂ 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF BOSUTINIB

The present invention provides an improved process for the preparation of bosutinib and its intermediate 2-cyano-N-(2, 4-dichloro-5-methoxyphenyl)acetamide.

Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles

Compound 1 (SKI-606, bosutinib), a 7-alkoxy-4-[(2,4-dichloro-5- methoxyphenyl)amino]-3-quinolinecarbonitrile, is a potent inhibitor of Src kinase activity. We previously reported that analogs of 1 with thiophene groups at C-7 retained the Src activity of

Process for preparation of 4-amino-3-quinolinecarbonitriles

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.