846606-25-5

Basic information

• Product Name: Cyclohexanone, 3-[4-(1,1-dimethylethyl)phenyl]-, (3R)-
• CAS NO: 846606-25-5
• Molecular Formula: C16H22O
• Molecular Weight: 230.35
• Mol File: 846606-25-5.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 3-[4-(1,1-dimethylethyl)phenyl]-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 3-[4-(1,1-dimethylethyl)phenyl]-, (3R)-(846606-25-5)
• EPA Substance Registry System: Cyclohexanone, 3-[4-(1,1-dimethylethyl)phenyl]-, (3R)-(846606-25-5)

Safety Data

• Hazardous Substances Data: 846606-25-5(Hazardous Substances Data)

Upstream product

• 930-68-7 cyclohexenone 
• 123324-71-0 p-tert-butylphenylboronic acid 

Relevant articles and documents

Tricyclic Sulfoxide-Alkene Hybrid Ligands for Chiral Rh(I) Complexes: The "Matched" Diastereomer Catalyzes Asymmetric C-C Bond Formations

Deprotonation of phenyldibenzo[b,f]tropylidene (8) with LDA/t-BuOK followed by quenching with either diastereomer of inexpensive glucose-based t-Bu-sulfinate (R)- or (S)-11 affords a sulfoxide-alkene hybrid ligand as the diastereomeric pairs (SS,SC)-9/(SS,RC)-10 and (RS,RC)-9/(RS,SC)-10, respectively, which via chromatographic/recrystallization may be separated into the four isomers. The optically pure diastereomeric ligands (SS,SC)-9 and (SS,RC)-10 react with [RhCl(coe)2]2 to form the dinuclear complexes (RS,SC)-11 and (RS,RC)-12, respectively, in which the bidentate ligands coordinate the metal centers through the sulfur and alkene donor functions. These complexes catalyze the conjugate addition of arylboronic acids to cyclic Michael acceptors with enantioselectivities of up to 99% ee. DFT calculations show the preponderant influence of planar chirality of the ligand alkene function. The enantioselectivity switch observed between (RS,SC)-11 and (RS,RC)-12 is explained by the inverted cis-trans coordinations of the substrate molecules in catalytic steps.

A novel, C2-symmetric, chiral bis-cyclosulfinamide-olefin tridentate ligand in Rh-catalyzed asymmetric 1,4-additions

A C2-symmetric, chiral bis-cyclosulfinamide-olefin ligand composed of two 1-oxo-2,3-dihydro-1,2-benzisothiazole moieties with rigid skeletons and a conformationally flexible butenylene chain is disclosed for the first time. HRMS and 1/sup

A New Type of Chiral Cyclic Sulfinamide–Olefin Ligands for Rhodium-Catalyzed Asymmetric Addition

A new type of chiral cyclic sulfinamide–olefin ligands, N-allylic 2,3-dihydro-1,2-benzoisothiazole 1-oxides, with 2,3-dihydro-1,2-benzoisothiazole 1-oxide as a unique chiral skeleton, is developed for the highly enantioselective rhodium-catalyzed asymmetr