84670-23-5

Basic information

• Product Name: 1-Methyl-3-phenylcarbamoylmethyl-1H-indole-2-carboxylic acid
• CAS NO: 84670-23-5
• Molecular Weight: 308.337
• Mol File: 84670-23-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Methyl-3-phenylcarbamoylmethyl-1H-indole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-3-phenylcarbamoylmethyl-1H-indole-2-carboxylic acid(84670-23-5)
• EPA Substance Registry System: 1-Methyl-3-phenylcarbamoylmethyl-1H-indole-2-carboxylic acid(84670-23-5)

Safety Data

• Hazardous Substances Data: 84670-23-5(Hazardous Substances Data)

Upstream product

• 60442-30-0 1,3-dioxo-9-methyl-1H,3H,4H,9H-indolo<2,3-c>pyran 
• 62-53-3 aniline 

Downstream Products

• 94575-23-2 1-Methyl-3-(N-phenylcarbamoylmethyl)-1H-indole 
• 1912-48-7 2-(1-methyl-1H-indol-3-yl)acetic acid 

Relevant articles and documents

Reaction of 2-Carboxy-1-methylindole-3-acetic Acid Anhydride with Amines and with S-Methylisothiosemicarbazide

2-Carboxy-1-alkylindole-3-acetic acid anhydrides (I) condensed with S-methylisothiosemicarbazide in DMF to form 5,11-dihydro-6-methyl-2-methylthioindolopyrido-s-triazol-5-one (II).Compound II underwent ring opening on refluxing with sodium hydroxide solution to give IV.The anhydride I reacted with primary amines in benzene to give 2-carboxy-1-alkylindole-3-acetanilide derivatives (VI) which yielded 1-methylindole-3-acetic acid by decarboxylation followed by hydrolysis.Compound II oxidised to the diketo compound X which could be prepared by the hydrolysis of the azomethine derivative IX with acetic acid-hydrochloric acid mixture.Compound II reacted with benzyl chloride to yield the dibenzyl derivative XII, condensed with p-chlorobenzaldehyde to form the 11-p-chlorobenzylidene derivative XI and coupled with arenediazonium salt to give the 11-arylhydrazone derivatives XIII.