847156-32-5

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[4-[(3-fluorophenyl)methoxy]phenoxy]-, 1,1-dimethylethyl ester
• CAS NO: 847156-32-5
• Molecular Formula: C23H28FNO4
• Molecular Weight: 401.478
• Mol File: 847156-32-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[4-[(3-fluorophenyl)methoxy]phenoxy]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[4-[(3-fluorophenyl)methoxy]phenoxy]-, 1,1-dimethylethyl ester(847156-32-5)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[4-[(3-fluorophenyl)methoxy]phenoxy]-, 1,1-dimethylethyl ester(847156-32-5)

Safety Data

• Hazardous Substances Data: 847156-32-5(Hazardous Substances Data)

Upstream product

• 681484-29-7 4-(4-hydroxyphenoxy)piperidine-1-carboxylic acid tert-butyl ester 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 847156-34-7 methyl 4-{4-[(3-fluorobenzyl)oxy]phenoxy}piperidine-1-carboxylate 

Relevant articles and documents

Synthesis and structure-activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: Effects on heart failure

In the context of heart failure and myocardial ischemia reperfusion, the activity of the sodium-calcium exchanger can lead to calcium overload, which in turn can lead to contractile dysfunction and arrhythmia. Therefore, NCX is an attractive target for treatment of heart failure and myocardial ischemia reperfusion. We have designed and synthesized a series of benzyloxyphenyl derivatives as potential NCX inhibitors, based on compound 4. These derivatives have been evaluated for their inhibitory activity against both the reverse and forward modes of NCX, and two novel potent NCX inhibitors (7i, 10a) were discovered. Compound 7i was evaluated for its efficacy on ouabain-induced tonotropy and arrhythmia in a heart-failure model.