847199-90-0

Basic information

• Product Name: Carbamic acid, [(1R)-2-(1H-indol-3-yl)-1-methylethyl]-, 1,1-dimethylethyl ester
• Synonyms: tert-butyl (R)-1-(1H-indol-3-yl)propan-2-ylcarbamate;[(R)-2-(1H-Indol-3-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester
• CAS NO: 847199-90-0
• Molecular Formula: C16H22N2O2
• Molecular Weight: 274.363
• Mol File: 847199-90-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1R)-2-(1H-indol-3-yl)-1-methylethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R)-2-(1H-indol-3-yl)-1-methylethyl]-, 1,1-dimethylethyl ester(847199-90-0)
• EPA Substance Registry System: Carbamic acid, [(1R)-2-(1H-indol-3-yl)-1-methylethyl]-, 1,1-dimethylethyl ester(847199-90-0)

Safety Data

• Hazardous Substances Data: 847199-90-0(Hazardous Substances Data)

Usage

General Description

The chemical "Carbamic acid, [(1R)-2-(1H-indol-3-yl)-1-methylethyl]-, 1,1-dimethylethyl ester" is a compound belonging to the carbamic acid ester group. It is also known as Propanolol Carbamate, a derivative of propanolol, which is a beta-blocker medication used to treat heart conditions, high blood pressure, and anxiety. Propanolol Carbamate is used as an intermediate in the synthesis of various pharmaceutical compounds and is also studied for its potential therapeutic effects in the treatment of other conditions. It is a colorless solid with a characteristic odor, and its chemical structure consists of a carbamic acid moiety linked to a 1R-2-(1H-indol-3-yl)-1-methylethyl group and a 1,1-dimethylethyl ester group.

Upstream product

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Downstream Products

• 7795-52-0 (-)-alpha-Methyltryptamine 
• 847200-08-2 thiophene-2-sulfonic acid (3-{1-(tert-butyl-dimethyl-silanyloxy)-2-[2-(1-ethyl-1H-indol-3-yl)-1-methyl-ethylamino]-ethyl}-phenyl)-amide 

Relevant articles and documents

PROCESSES FOR MAKING SERD TRICYCLIC COMPOUNDS HAVING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY

Provided herein are processes for the preparation of compounds useful in the treatment of cancer.

SOLID FORMS OF 3-((1R,3R)-1-(2,6-DIFLUORO-4-((1-(3-FLUOROPROPYL)AZETIDIN-3-YL)AMINO)PHENYL)-3-METHYL-1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOL-2-YL)-2,2-DIFLUOROPROPAN-1-OL AND PROCESSES FOR PREPARING FUSED TRICYCLIC COMPOUNDS COMPRISING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY, INCLUDING METHODS OF THEIR USE

Provided herein are solid forms, salts such as compound B, and formulations of 3-((lR,3R)-l-(2,6-difluoro-4-((l-(3-fluoropropyl) azetidin-3-yl)amino)phenyl)-3-methyl-l,3,4,9-tetrahydro-2H- pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-l-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.

N-Acyl glycinates as acyl donors in serine protease-catalyzed kinetic resolution of amines. Improvement of selectivity and reaction rate

Enzymatic kinetic resolution of aliphatic and benzylic amines leading to (S)-amides was achieved by using alkaline protease as the catalyst and N-octanoyl glycine trifluoroethyl ester as the acyl donor; enantioselectivity ranged between 4 to 244, while reaction times were dramatically shortened and ranged between 15 min to 6 h. The 2008 Royal Society of Chemistry.