84746-24-7 Usage
Description
2,2'-(1,4-Piperazinediyl)bis-pyrimidine is an organic compound that serves as an impurity in Buspirone, a non-benzodiazepine anxiolytic medication. It is characterized by its unique structure, which includes a 1,4-piperazinediyl bridge connecting two pyrimidine rings. 2,2'-(1,4-Piperazinediyl)bis-pyrimidine plays a role in the pharmaceutical industry due to its association with Buspirone, which is a 5-hydroxytryptamine (5-HT1) receptor agonist.
Uses
Used in Pharmaceutical Industry:
2,2'-(1,4-Piperazinediyl)bis-pyrimidine is used as an impurity in the production of Buspirone (B689850), a non-benzodiazepine anxiolytic medication. It is important for the pharmaceutical industry to monitor and control the presence of this impurity to ensure the safety, efficacy, and quality of Buspirone as a 5-hydroxytryptamine (5-HT1) receptor agonist.
Check Digit Verification of cas no
The CAS Registry Mumber 84746-24-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,7,4 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 84746-24:
(7*8)+(6*4)+(5*7)+(4*4)+(3*6)+(2*2)+(1*4)=157
157 % 10 = 7
So 84746-24-7 is a valid CAS Registry Number.
84746-24-7Relevant articles and documents
Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-Triazole) mannich bases containing piperazine rings
Wang, Bao-Lei,Shi, Yan-Xia,Ma, Yi,Liu, Xing-Hai,Li, Yong-Hong,Song, Hai-Bin,Li, Bao-Ju,Li, Zheng-Ming
experimental part, p. 5515 - 5522 (2011/08/03)
A series of trifluoromethyl-substituted 1,2,4-triazole Mannich base 6 and bis(1,2,4-triazole) Mannich base 7 containing pyrimidinylpiperazine rings via the Mannich reaction were synthesized and characterized by infrared (IR), 1H nuclear magnetic resonance (NMR), and elemental analysis. The fungicidal tests indicated that most of compounds 6 and 7 possessed excellent fungicidal activity. Among 19 novel compounds, some showed superiority over commercial fungicides Dimethomorph, Thiophanate-methyl, Iprodione, and Zhongshengmycin. Some compounds also exhibited favorable herbicidal activity in the preliminary studies. On the basis of the comparative molecular field analysis (CoMFA), five novel compounds were subsequently synthesized, their activities were estimated fairly accurately, and compounds 6-A1 and 7-A2 displayed good fungicidal activity against Pseudoperonospora cubensis (96.9 and 84.9%) as 6h and 7c, respectively.
