84772-28-1

Basic information

• Product Name: 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride
• Synonyms: 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride
• CAS NO: 84772-28-1
• Molecular Weight: 251.716
• Mol File: 84772-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride(84772-28-1)
• EPA Substance Registry System: 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride(84772-28-1)

Safety Data

• Hazardous Substances Data: 84772-28-1(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 84772-29-2 ornithine ethyl ester dihydrochloride 

Downstream Products

• 84772-30-5 3-(2'-aminobenzoyl)aminopiperidin-2-one 
• 885-70-1 5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one 

Relevant articles and documents

Novel synthesis of 5,11-dihydro-6H-pyrido[2,3-b]-[1,4]-benzodiazepin-6-ones and related studies (1)

5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (1), a basic intermediate in the preparation of 11-α-aminoacetyl derivatives with important biological activities, has been obtained by a three-step synthesis starting from easily available isatoic anhydride and anhydro ornithine. Some model cyclisation reactions leading to 5-member ring derivatives 10 and 12 instead of 7-member ring analogues of 1, are reported. Easy transformations of the tetrahydro congener of 1, i.e. compound 4 into 19, which actually represents a tetrahedral intermediate in the transformation of 5 into 4, is noticed. Further rearrangement of 19 into spiro compounds 20, and return of the latter into 5 is described.