84775-03-1Relevant articles and documents
A Catechol Receptor Model by Macrocyclic Polyamines
Kimura, Eiichi,Watanabe, Asuka,Kodama, Mutsuo
, p. 2063 - 2066 (2007/10/02)
18-Azacrown-6 (L) (as triprotonated species) has been shown to form stable 1:1 complexes with catechol (1) and its biological derivatives 2-8 in neutral pH solutions.Their stability constants βL were determined polarographically.The catechol receptor model L interacts with Dopa and dopamine with a similar order of βL to indicate that the residual donor groups on the catecholamines do not significantly contribute to the complex formation.L has similar affinities to methyl ether derivatives of catechols.Further, L associates with an adrenergic blocking agent, dichloroisoproterenol (10).It also recognizes other drugs or drug functions such as resorcinol (9), tropolone (11), salicylic acid (12), p-aminosalicylic acid (13), and α-picolinic acid (14).