84783-67-5

Basic information

• Product Name: 1-(4-methylsulphonylphenyl)thiourea
• Synonyms: 1-(4-methylsulphonylphenyl)thiourea;N-[4-(Methylsulfonyl)phenyl]thiourea;Einecs 284-104-3;Thiourea, N-[4-(Methylsulfonyl)phenyl]-;1-(4-(Methylsulfonyl)phenyl)thiourea;(4-Methanesulfonyl-phenyl)-thiourea;(4-methylsulfonylphenyl)thiourea
• CAS NO: 84783-67-5
• Molecular Formula: C₈H₁₀N₂O₂S₂
• Molecular Weight: 230.3072
• EINECS: 284-104-3
• Mol File: 84783-67-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 435.9°C at 760 mmHg
• Flash Point: 217.4°C
• Appearance: /
• Density: 1.445g/cm³
• Vapor Pressure: 8.42E-08mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-methylsulphonylphenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylsulphonylphenyl)thiourea(84783-67-5)
• EPA Substance Registry System: 1-(4-methylsulphonylphenyl)thiourea(84783-67-5)

Safety Data

• Hazardous Substances Data: 84783-67-5(Hazardous Substances Data)

Usage

Description

1-(4-methylsulphonylphenyl)thiourea is a chemical compound with the molecular formula C9H10N2O2S and a molecular weight of 210.26 g/mol. It is a thiourea derivative with a methylsulphonylphenyl group attached to the nitrogen atom.
Used in Agriculture:
1-(4-methylsulphonylphenyl)thiourea is used as a herbicide for controlling weeds in various crops. It works by inhibiting the enzyme acetolactate synthase, which is essential for the biosynthesis of branched-chain amino acids in plants. Due to its low toxicity to mammals and non-target organisms, it is considered a relatively safe option for agricultural use. However, proper handling and application protocols should be followed to minimize environmental impact and ensure worker safety.

InChI:InChI=1/C8H10N2O2S2/c1-14(11,12)7-4-2-6(3-5-7)10-8(9)13/h2-5H,1H3,(H3,9,10,13)

Upstream product

• 15863-56-6 1-isothiocyanato-4-methanesulfonyl-benzene 
• 5470-49-5 4-methanesulfonylphenylamine 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 100060-63-7 (4-methanesulfonyl-phenyl)-(4-methyl-thiazol-2-yl)-amine 
• 17557-67-4 2-amino-6-(methylsulfonyl)benzothiazole 

Relevant articles and documents

Riluzole series. synthesis and in vivo 'antiglutamate' activity of 6- substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines

Two series of analogues of riluzole, a blocker of excitatory amino acid mediated neurotransmission, have been synthesized: monosubstituted 2- benzothiazolamines and 3-substituted derivatives. Of all the compounds prepared in the first series, only 2-benzothiazolamines bearing alkyl, polyfluoroalkyl, or polyfluoroalkoxy substituents in the 6-position showed potent anticonvulsant activity against administration of glutamic acid in rats. The most active compounds displaying in vivo 'antiglutamate' activity were the 6-OCF3 (riluzole), 6-OCF2CF3, 6-CF3, and 6-CF2CF3 substituted derivatives with ED50 values between 2.5 and 3.2 mg/kg i.p. Among the second series of variously substituted benzothiazolines, compounds as active as riluzole or up to 3 times more potent were identified in two series: benzothiazolines bearing a β-dialkylaminoethyl moiety and compounds with an alkylthioalkyl chain and their corresponding sulfoxides and sulfones. The most potent derivatives were 2-imino-3-(2-methylthio)- and 2-imino-3-(2- methylsulfinyl)-ethyl-6-trifluoromethoxybenzothiazolines (61 and 64, ED50 = 1.0 and 1.1 mg/kg i.p., respectively). In addition, intraperitoneal administration of some of the best benzothiazolines protected mice from mortality produced by hypobaric hypoxia.