84794-38-7

Basic information

• Product Name: ISOBUTYRYL MELDRUM'S ACID
• Synonyms: ISOBUTYRYL MELDRUM'S ACID;5-(1-Hydroxy-2-Methylpropylidene)-2,2-diMethyl-1,3-dioxane-4,6-dione
• CAS NO: 84794-38-7
• Molecular Formula: C₁₀H₁₄O₅
• Molecular Weight: 214.22
• Product Categories: Aromatics
• Mol File: 84794-38-7.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: ISOBUTYRYL MELDRUM'S ACID(CAS DataBase Reference)
• NIST Chemistry Reference: ISOBUTYRYL MELDRUM'S ACID(84794-38-7)
• EPA Substance Registry System: ISOBUTYRYL MELDRUM'S ACID(84794-38-7)

Safety Data

• Hazardous Substances Data: 84794-38-7(Hazardous Substances Data)

Usage

Description

Isobutyryl Meldrum's Acid, with the chemical name 2,2-dimethoxy-1,3-dioxolane-4-acetic acid isobutyrate, is a versatile compound used in organic synthesis. It is characterized by its light brown oil appearance and possesses unique chemical properties that make it valuable in various applications.

Uses

Used in Organic Synthesis:
Isobutyryl Meldrum's Acid is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, facilitating the synthesis of complex molecules and pharmaceuticals.
Used in Pharmaceutical Industry:
Isobutyryl Meldrum's Acid is used as a building block in the development of new pharmaceuticals. Its reactivity and compatibility with other chemical entities make it a valuable component in the creation of novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
Isobutyryl Meldrum's Acid is utilized in academic and industrial research settings to explore new chemical reactions and mechanisms. Its unique properties provide opportunities for scientists to investigate new pathways and develop innovative synthetic strategies.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 79-30-1 isobutyryl chloride 
• 79-31-2 isobutyric Acid 

Downstream Products

• 851578-85-3 tert-butyl 5-(aminomethyl)-6-(2,2-dimethylpropyl)-2-(1-methylethyl)-4-(4-methylphenyl)pyridine-3-carboxylate 
• 851578-87-5 tert-butyl 5-cyano-6-(2,2-dimethylpropyl)-2-(1-methylethyl)-4-(4-methylphenyl)pyridine-3-carboxylate 
• 851578-86-4 tert-butyl 5-cyano-2-isopropyl-4-(4-methylphenyl)-6-neopentyl-1,4-dihydropyridine-3-carboxylate 
• 235087-30-6 4-tert-butoxycarbonyl-2-methyl-7-phenylhept-3-en-3-yl trifluoromethanesulfonate 
• 235087-26-0 tert-butyl 4-methyl-3-oxo-2-(3-phenylpropyl)pentanoate 
• 725340-63-6 tert-butyl 2-isobutyryl-5-phenylpent-2-enoate 
• 1026389-54-7 2-{2-[1-Dimethylamino-meth-(Z)-ylidene]-4-methyl-3-oxo-pentanoyloxymethyl}-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Interrupted Baeyer–Villiger Rearrangement: Building A Stereoelectronic Trap for the Criegee Intermediate

The instability of hydroxy peroxyesters, the elusive Criegee intermediates of the Baeyer–Villiger rearrangement, can be alleviated by selective deactivation of the stereoelectronic effects that promote the 1,2-alkyl shift. Stable cyclic Criegee intermediates constrained within a five-membered ring can be prepared by mild reduction of the respective hydroperoxy peroxyesters (β-hydroperoxy-β-peroxylactones) which were formed in high yields in reaction of β-ketoesters with BF3?Et2O/H2O2.

Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists

The farnesoid X receptor (FXR) may play a crucial role in a number of metabolic diseases and, as such, could potentially serve as a target for the development of therapeutics as a treatment for those diseases. Previous work has described GW4064 as an FXR

Creation through immobilization: A new family of high performance heterogeneous bifunctional iminophosphorane (BIMP) superbase organocatalysts

An immobilized chiral bifunctional iminophosphorane superbase organocatalyst has been developed and applied in a range of challenging enantioselective reactions. A unique feature of this novel catalytic system is that the final step creation of the iminophosphorane occurs at the point of immobilization. The utility of the immobilized catalyst system was demonstrated in the nitro-Mannich reaction of ketimines as well as the conjugate addition of high pKa 1,3-dicarbonyl pro-nucleophiles to nitrostyrene. Catalyst recycling was also demonstrated.