847981-73-1Relevant articles and documents
A novel class of potent influenza virus inhibitors: Polysubstituted acylthiourea and its fused heterocycle derivatives
Sun, Chuanwen,Huang, Hai,Feng, Meiqing,Shi, Xunlong,Zhang, Xiaodong,Zhou, Pei
, p. 162 - 166 (2007/10/03)
A series of polysubstituted and fused heterocycle derivatives of acylthiourea was prepared and the biological activity against influenza virus was evaluated. Of the analogues that demonstrated IC50s 0.1 μM, acylthiourea derivatives 16 and 50 were further investigated as candidates with the most potential for future development. The SAR of these compounds are discussed and they represent a novel class of highly potent and selective inhibitors of influenza virus.
Ultrasonic irradiated synthesis of N-(5-aryl-2-furoyl)thiourea derivatives containing substituted pyrimidine ring under phase transfer catalysis
Xue, Si-Jia,Ke, Shao-Yong,Wei, Tai-Bao,Duan, Li-Ping,Guo, Yan-Ling
, p. 1013 - 1018 (2007/10/03)
A series of N-(5-aryl-2-furoyl)thiourea derivatives containing substituted pyrimidine ring were synthesized in good yield using PEG-400 as solid-liquid phase transfer catalyst under ultrasonic irradiation. The structures of all newly synthesized compounds
