848130-83-6

Basic information

• Product Name: 8-Azabicyclo[3.2.1]octane-3-thiol, 8-methyl-, (3-exo)-
• CAS NO: 848130-83-6
• Molecular Formula: C8H15NS
• Molecular Weight: 157.28
• Mol File: 848130-83-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-Azabicyclo[3.2.1]octane-3-thiol, 8-methyl-, (3-exo)-(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Azabicyclo[3.2.1]octane-3-thiol, 8-methyl-, (3-exo)-(848130-83-6)
• EPA Substance Registry System: 8-Azabicyclo[3.2.1]octane-3-thiol, 8-methyl-, (3-exo)-(848130-83-6)

Safety Data

• Hazardous Substances Data: 848130-83-6(Hazardous Substances Data)

Usage

General Description

8-Azabicyclo[3.2.1]octane-3-thiol, 8-methyl-, (3-exo)-, also known as exo-8-methyl-3-thia-8-azabicyclo[3.2.1]octane, is a chemical compound with a molecular formula of C8H15NS. It is a cyclic organic compound with a sulfur atom and a methyl group attached to a nitrogen atom within the 8-membered ring structure. 8-Azabicyclo[3.2.1]octane-3-thiol, 8-methyl-, (3-exo)- is commonly used in organic synthesis and pharmaceutical research as a building block for various medicinal and chemical compounds. It may also have applications in the field of catalysis and as a reagent in chemical reactions. Additionally, it may possess certain biological activities which could make it of interest in the study of pharmacological and biochemical processes.

Upstream product

• 35130-97-3 (1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl-methane sulfonate 

Downstream Products

• 224452-66-8 retapamulin 

Relevant articles and documents

A prepares switzerland he Moline method

The invention discloses a method for preparing retapamulin. The method comprises the following steps that a compound of a formula 3 and a compound of a formula 4 are subjected to a nucleophilic substitution reaction to obtain a compound of a formula 5; the compound of the formula 5 is subjected to a hydrolysis reaction to obtain beta-tropine mercaptan shown in a formula 6; the beta-tropine mercaptan shown in the formula 6 is not separated and purified to be subjected to condensation with a compound of a formula 2 to obtain retapamulin 1; the reaction formula is shown in the specification, wherein M in the compound of the formula 4 is a metal ion of a potassium ion or a sodion or a calcium ion or an iron ion or an ammonium ion, n corresponds to the valence of the metal ion M and is 1 or 2 or 3, and R is alkyl groups C1-C3 or a phenyl group or a substituted phenyl group or a benzyl group or a substituted benzyl group. The method is easy and convenient to implement, a cheap reagent is adopted, the influences on the environment are greatly reduced, intermediate products are easy to purify, no column chromatography is needed, the defects of reported methods for preparing beta-tropine mercaptan and retapamulin are overcome, and the method has obvious positive and progressive effects and practical application value.