848175-28-0

Basic information

• Product Name: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide
• Synonyms: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide
• CAS NO: 848175-28-0
• Molecular Weight: 287.361
• Mol File: 848175-28-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide(848175-28-0)
• EPA Substance Registry System: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide(848175-28-0)

Safety Data

• Hazardous Substances Data: 848175-28-0(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 39889-69-5 biphenyl-4-yl-acetyl chloride 

Relevant articles and documents

Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages

The construction of amide bonds and peptide linkages is one of the most fundamental transformations in all life processes and organic synthesis. The synthesis of structurally ubiquitous amide motifs is essential in the assembly of numerous important molecules such as peptides, proteins, alkaloids, pharmaceutical agents, polymers, ligands and agrochemicals. A method of SO2F2-mediated direct clickable coupling of carboxylic acids with amines was developed for the synthesis of a broad scope of amides in a simple, mild, highly efficient, robust and practical manner (>110 examples, >90% yields in most cases). The direct click reactions of acids and amines on a gram scale are also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields.

The ketene-surrogate coupling: Catalytic conversion of aryl iodides into aryl ketenes through ynol ethers

tert-Butoxyacetylene is shown to undergo Sonogashira coupling with aryl iodides to yield aryl-substituted tert-butyl ynol ethers. These intermediates participate in a [1,5]-hydride shift, which results in the extrusion of isobutylene and the generation of aryl ketenes. The ketenes are trapped in situ with multiple nucleophiles or undergo electrocyclic ring closure to yield hydroxynaphthalenes and quinolines.