848258-31-1

Basic information

• Product Name: 2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]minomethyl]phenoxy]butyric acid
• CAS NO: 848258-31-1
• Molecular Weight: 490.556
• Mol File: 848258-31-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]minomethyl]phenoxy]butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]minomethyl]phenoxy]butyric acid(848258-31-1)
• EPA Substance Registry System: 2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]minomethyl]phenoxy]butyric acid(848258-31-1)

Safety Data

• Hazardous Substances Data: 848258-31-1(Hazardous Substances Data)

Usage

Molecular structure

The compound contains a benzoxazole ring, a propylamine group, a phenoxy group, and a butyric acid chain.

Type of compound

It is a complex organic compound and a derivative of fatty acid.

Substituents

The compound has a benzoxazole-2-yl substituent and a 3-(4-methoxyphenoxy)propyl group attached to the nitrogen atom of the propylamine group.

Biological activity

The compound has potential biological activity, which may have applications in pharmaceutical and agricultural industries.

Unique structure

The compound's unique structure suggests that it may have diverse and interesting chemical and biological effects.

Lack of documentation

Its precise properties and applications are not well documented, and further research and testing are necessary to fully understand its potential.

Upstream product

• 907192-61-4 n-butyl (R)-2-[3-[[benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoate 
• 615-18-9 2-chloro-1,3-benzoxazole 
• 100-83-4 meta-hydroxybenzaldehyde 
• 100841-00-7 3-(4-methoxyphenoxy)propan-1-amine 
• 63815-39-4 2-(4-Methoxyphenoxy)cyanoethane 
• 150-76-5 4-methoxy-phenol 
• 95-55-6 2-amino-phenol 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 
• 692753-51-8 methyl (S)-2-chlorobutanoate 
• 907192-60-3 n-butyl (S)-2-trifluoromethanesulfonyl-oxybutanoate 
• 907192-63-6 (S)-2-p-toluenesulfonyloxy-butanoic acid phenethyl ester 
• 907192-64-7 (S)-2-methanesulfonyloxy-butanoic acid n-butyl ester 
• 907192-65-8 (S)-2-p-toluenesulfonyloxy-butanoic acid n-butyl ester 
• 909272-20-4 n-butyl (R)-2-[3-[N-[3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyrate 

Relevant articles and documents

A practical synthesis of the PPARα agonist, (R)-K-13675, starting from (S)-2-hydroxybutyrolactone

A practical synthesis of optically pure PPARα agonist, (R)-K-13675, is described. This process is based on the use of (S)-2-hydroxybutyrolactone, which can be transformed into the requisite n-butyl (S)-2-hydroxybutanoate in an efficient manner. A key reaction is the etherification between the phenol and n-butyl (S)-2-trifluoromethanesulfonyloxybutanoate to give the phenyl ether in excellent yield without loss of optical purity.

Enantioselective synthesis of the PPARα agonist (R)-K-13675 via (S)-2-hydroxybutyrolactone

Enantioselective synthesis of enantiomerically pure PPARα agonist (R)-K-13675 can be achieved starting from (S)-2-hydroxybutyrolactone. An important intermediate, 2-(aryloxy)butyrolactone, was prepared by reaction of the phenol with (S)-2-hydroxybutyrolactone in excellent yield without loss of enantiomeric purity using the Mitsunobu reaction, followed by conversion into the 2-(aryloxy)butanoic acid via the 2-(aryloxy)-4-iodobutanoate by cleavage of the lactone on exposure to iodotrimethylsilane, followed by hydrogenolysis and hydrolysis. Georg Thieme Verlag Stuttgart.

OPTICALLY ACTIVE PPAR-ACTIVATING COMPOUND INTERMEDIATE AND METHOD FOR PRODUCING SAME

The present invention provides a production intermediate for compound (A-1) and a method for producing the intermediate at high yield and high optical yield. The present invention provides a method for producing compound (3) characterized in that compound