84828-97-7Relevant articles and documents
A double-headed nucleotide with two cytosines: DNA with condensed information and improved duplex stability
Beck, Kasper,Reslow-Jacobsen, Charlotte,Hornum, Mick,Henriksen, Christian,Nielsen, Poul
, p. 740 - 743 (2019)
Double-headed nucleotide monomers are capable of condensing the genetic information of DNA. Herein, a double-headed nucleotide with two cytosine bases (CC) is constructed. The additional cytosine is connected through a methylene linker to the 2
Synthesis of 2'-deoxy-2'-spirocyclopropyl cytidine as potential inhibitor of ribonucleotide diphosphate reductase
Czernecki,Mulard,Valery,Commercon
, p. 413 - 416 (1993)
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New insight into the mechanism of base propenal formation during bleomycin-mediated DNA degradation
McGall,Rabow,Ashley,Wu,Kozarich,Stubbe
, p. 4958 - 4967 (1992)
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Nucleosides and Nucleotides. 102. Stereoselective Radical Deoxygenation of Tert-Propargyl Alcohols in Sugar Moiety of Pyrimidine Nucleosides: Synthesis of 2'-C-Alkynyl-2'-Deoxy-1-β-D-Arabinofuranosylpyrimidines
Yoshimura, Yuichi,Iino, Tomoharu,Matsuda, Akira
, p. 6003 - 6006 (1991)
Synthesis of the title compounds can be achieved by nucleophilic addition of lithium salts of TMSacetylene and 1-hexyne to 2'-ketouridine followed by radical deoxygenation of the corresponding methoxyaryl ester.Key Words: radical deoygenation; propargyl alcohol; ethynyl substituent; acetylene
Base-Pairing Properties of Double-Headed Nucleotides
Hornum, Mick,Stendevad, Julie,Sharma, Pawan K.,Kumar, Pawan,Nielsen, Rasmus B.,Petersen, Michael,Nielsen, Poul
, p. 7387 - 7395 (2019/05/16)
Nucleotides that contain two nucleobases (double-headed nucleotides) have the potential to condense the information of two separate nucleotides into one. This presupposes that both bases must successfully pair with a cognate strand. Here, double-headed nucleotides that feature cytosine, guanine, thymine, adenine, hypoxanthine, and diaminopurine linked to the C2′-position of an arabinose scaffold were developed and examined in full detail. These monomeric units were efficiently prepared by convergent synthesis and incorporated into DNA oligonucleotides by means of the automated phosphoramidite method. Their pairing efficiency was assessed by UV-based melting-temperature analysis in several contexts and extensive molecular dynamics studies. Altogether, the results show that these double-headed nucleotides have a well-defined structure and invariably behave as functional dinucleotide mimics in DNA duplexes.
Novel 2'-fluorouracil nucleoside and synthetic method
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Paragraph 0014, (2019/01/05)
The invention discloses a novel 2'-fluorouracil nucleoside and a synthetic method. A structural general formula of a compound is shown as the specification, and the synthetic method comprises the following steps in the specification. The synthesis method