84860-21-9

Basic information

• Product Name: (S)-2-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid methyl ester
• Synonyms: (S)-2-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid methyl ester
• CAS NO: 84860-21-9
• Molecular Weight: 481.546
• Mol File: 84860-21-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid methyl ester(84860-21-9)
• EPA Substance Registry System: (S)-2-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid methyl ester(84860-21-9)

Safety Data

• Hazardous Substances Data: 84860-21-9(Hazardous Substances Data)

Upstream product

• 2389-60-8 Z-Lys(Boc)-OH 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 

Downstream Products

• 474686-25-4 2-(1-{[2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carbonyl]-amino}-3-tert-butoxycarbonyl-propyl)-thiazole-4-carboxylic acid ethyl ester 
• 474686-46-9 2-(1-{[2-(1-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propyl)-thiazole-4-carbonyl]-amino}-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester 
• 474686-27-6 2-((4S,13S)-13-Benzyloxycarbonylamino-2,10-dioxo-15-thia-3,9,17-triaza-bicyclo[12.2.1]heptadeca-1⁽¹⁶⁾,14⁽¹⁷⁾-dien-4-yl)-oxazole-4-carboxylic acid 
• 474686-23-2 2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid 
• 474686-33-4 2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester 

Relevant articles and documents

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity

A series of 24-membered macrocyclic hexaoxazoles containing one or two aminoalkyl substituents was synthesized and evaluated for cytotoxicity and for their ability to selectively stabilize G-quadruplex DNA and RNA. The most cytotoxic analog 4a, with IC50 values of 25 and 130 nM using KB3-1 and RPMI 8402 cells, is efficacious in vivo in athymic nude mice with a human tumor xenograft from the breast cancer cell line MDA-MB-435.