848644-38-2

Basic information

• Product Name: 1-[2,3,5-tri-O-acetyl-3-C-ethynyl-β-D-ribo-pentofuranosyl]-4-N-benzoylcytosine
• Synonyms: 1-[2,3,5-tri-O-acetyl-3-C-ethynyl-β-D-ribo-pentofuranosyl]-4-N-benzoylcytosine
• CAS NO: 848644-38-2
• Molecular Weight: 497.461
• Mol File: 848644-38-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[2,3,5-tri-O-acetyl-3-C-ethynyl-β-D-ribo-pentofuranosyl]-4-N-benzoylcytosine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2,3,5-tri-O-acetyl-3-C-ethynyl-β-D-ribo-pentofuranosyl]-4-N-benzoylcytosine(848644-38-2)
• EPA Substance Registry System: 1-[2,3,5-tri-O-acetyl-3-C-ethynyl-β-D-ribo-pentofuranosyl]-4-N-benzoylcytosine(848644-38-2)

Safety Data

• Hazardous Substances Data: 848644-38-2(Hazardous Substances Data)

Upstream product

• 35810-59-4 (3aR,5R,6R,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-6-ethynyl-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol 
• 155470-63-6 3-C-ethynyl-1,2-O-isopropylidene-α-D-ribo-pentofuranose 
• 97694-32-1 1,2-O-isopropylidene-3-C-ethynyl-α-D-allofuranose 
• 97694-33-2 3-C-ethynyl-1,2-O-isopropylidene-α-D-ribo-pentodialdo-1,4-furanose 
• 861444-58-8 Acetic acid (3aR,5R,6R,6aR)-5-acetoxymethyl-6-ethynyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 848644-37-1 1,2,3,5-tetra-O-acetyl-3-C-ethynyl-D-ribo-pentofuranose 
• 26661-13-2 4-N-benzoylcytosine 

Downstream Products

• 180300-43-0 3'-ethynylcytidine 

Relevant articles and documents

Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3′-C-ethynyluridine (EUrd) and 3′-C- ethynylcytidine (ECyd)

A series of nucleobase-modified analogs of the anticancer compounds 3′-C-ethynyluridine (EUrd) and 3′-C-ethynylcytidine (ECyd) were designed to overcome the strict substrate specificity of the activating uridine-cytidine kinase. EUrd, ECyd and target nucleosides were obtained using a short convergent synthetic route utilizing diacetone-α-d-glucose as starting material. 5-Iodo-substituted EUrd was the most potent inhibitor among the novel nucleobase-modified analogs in in vitro assays against human adenocarcinoma breast and prostate cancer cells with IC50 values down to 35 nM.