848674-84-0

Basic information

• Product Name: (R)-N-methyl-N-methoxy-3-(4-methylphenyl)butanamide
• Synonyms: (R)-N-methyl-N-methoxy-3-(4-methylphenyl)butanamide
• CAS NO: 848674-84-0
• Molecular Weight: 221.299
• Mol File: 848674-84-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-N-methyl-N-methoxy-3-(4-methylphenyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-methyl-N-methoxy-3-(4-methylphenyl)butanamide(848674-84-0)
• EPA Substance Registry System: (R)-N-methyl-N-methoxy-3-(4-methylphenyl)butanamide(848674-84-0)

Safety Data

• Hazardous Substances Data: 848674-84-0(Hazardous Substances Data)

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 93922-52-2 (R)-3-(4-methylphenyl)butanoic acid 
• 5720-05-8 4-methylphenylboronic acid 
• 109480-79-7 (E)-N-methoxy-N-methyl-2-butenamide 
• 106-38-7 para-bromotoluene 
• 122-00-9 para-methylacetophenone 
• 6305-61-9 ethyl (E)-3-p-tolylbut-2-enoate 
• 1376710-72-3 (E)-N-methoxy-N-methyl-3-(p-tolyl)but-2-enamide 
• 192512-81-5 (R)-3-(4-methylphenyl)butanenitrile 
• 35675-44-6 4-methylphenylacetyl chloride 
• 93922-51-1 (S)-2-(4-methylphenyl)-1-propanol 
• 23430-44-6 (S)-2-(4-methylphenyl)-1-propyl p-toluenesulfonate 
• 622-47-9 4-tolylacetic acid 
• 848674-80-6 (4S,2'S)-4-benzyl-3-[(4-methylphenyl)-2-propanoyl]-2-oxazolidinone 

Downstream Products

• 1141-54-4 (R)-2-methyl-6-(4-methylphenyl)-2-hepten-4-one 

Relevant articles and documents

Highly enantioselective asymmetric hydrogenation of (E)-β,β- disubstituted α,β-unsaturated Weinreb amides catalyzed by Ir(i) complexes of SpinPhox ligands

The Ir(i) complexes of chiral spiro phosphino-oxazoline ligands (SpinPhox) have demonstrated good to excellent enantioselectivity in the asymmetric hydrogenation (AH) of a variety of (E)-β,β-disubstituted α,β-unsaturated N-methoxy-N-methylamides, affording the corresponding optically active Weinreb amides with up to 97% ee.

Synthesis of (R)-ar-turmerone and its conversion to (R)-ar-himachalene, a pheromone component of the flea beetle: (R)-ar-himachalene is dextrorotatory in hexane, while levorotatory in chloroform

(R)-ar-Turmerone was synthesized from (4-methylphenyl)acetic acid by employing Evans asymmetric alkylation as the key step. (R)-ar-Turmerone was converted to (R)-ar-himachalene, which was dextrorotatory in hexane while levorotatory in chloroform. Enantiomerically impure (75% ee) (R)-3-(4-methylphenyl)butanoic acid crystallized more readily than the enantiomerically pure one.