848694-10-0

Basic information

• Product Name: 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine 1-Oxide
• Synonyms: 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine 1-Oxide;2-(chloromethyl)-4-methoxy-3,5-dimethyl-1-oxidopyridin-1-ium;Esomeprazole Impurity 27;2-(chloromethyl)-4-methoxy-3,5-dimethyl-1-oxidopyridin-1
• CAS NO: 848694-10-0
• Molecular Formula: C9H12ClNO2
• Molecular Weight: 201.65008
• Product Categories: Aromatics;Heterocycles;Intermediates
• Mol File: 848694-10-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 383.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: Dichloromethane
• PKA: 2.22±0.10(Predicted)
• CAS DataBase Reference: 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine 1-Oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine 1-Oxide(848694-10-0)
• EPA Substance Registry System: 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine 1-Oxide(848694-10-0)

Safety Data

• Hazardous Substances Data: 848694-10-0(Hazardous Substances Data)

Usage

Uses

Intermediate in the production of the antiulcer agent Omeprazole

Upstream product

• 86604-75-3 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride 

Downstream Products

• 142885-92-5 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzimidazole 

Relevant articles and documents

Synthesis and characterization of metabolites and potential impurities of the antiulcerative drug tenatoprazole

Tenatoprazole (Ulsacare) is a recently developed antiulcerative drug used for the treatment of both erosive and nonerosive gastroesophageal reflux disease. During the bulk synthesis of tenatoprazole, we have observed four impurities (tenatoprazole N-oxide, tenatoprazole sulfone N-oxide, N-methyl tenatoprazole, and desmethoxy tenatoprazole) and two metabolites (tenatoprazole sulfide and tenatoprazole sulfone). The present work describes the synthesis and characterization of these impurities. Copyright Taylor & Francis Group, LLC.

NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS

Novel heterocyclic compounds are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.