84905-80-6

Basic information

• Product Name: 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE
• Synonyms: 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE;4-Chloro-5H-pyrrol[3,2-d] pyrimidine;5H-Pyrrolo3,2-dpyrimidine, 4-chloro-;4-chloro-5H-pyrrolo[2,3-c]pyridine;4-Chloro-5H-pyrrolo[3,2-d...;6-chloro-9-deaza-7H-purine, 4-chloro-3H,5H-pyrrolo[3,2-d]pyriMidine, 4-ChloropyrrolopyriMidine;4-chloro-1H-pyrrolo[3,2-d]pyriMidine
• CAS NO: 84905-80-6
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.57
• EINECS: 1533716-785-6
• Product Categories: Heterocycles series;CHIRAL CHEMICALS;Heterocycle-Pyrimidine series
• Mol File: 84905-80-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 186-188 °C (decomp)(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 325.9 °C at 760 mmHg
• Flash Point: 180.7 °C
• Appearance: /
• Density: 1.531 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 11.58±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE(84905-80-6)
• EPA Substance Registry System: 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE(84905-80-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 84905-80-6(Hazardous Substances Data)

Usage

Description

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine is a chlorinated pyrrolopyrimidine, a type of heterocyclic compound characterized by the presence of nitrogen and sulfur atoms in its structure. 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE serves as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique chemical properties and potential biological activities.

Uses

Used in Pharmaceutical Industry:
4-Chloro-5H-pyrrolo[3,2-d]pyrimidine is used as a building block for the development of new drugs with antibacterial and antitumor activities. Its presence in the molecular structure of these drugs allows for the modulation of specific biological targets, leading to the inhibition of bacterial growth or the suppression of tumor progression.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine is utilized as a precursor in the synthesis of pesticides and herbicides. Its incorporation into these compounds enables the targeting of specific pests or weeds, thereby enhancing crop protection and yield.
Overall, 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine plays a significant role in both the pharmaceutical and agrochemical industries, contributing to the development of effective treatments and protection measures against various diseases and pests.

Upstream product

• 5655-01-6 9-deazahypoxanthine 
• 5655-01-6 3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one 

Downstream Products

• 666831-00-1 (3R,4R)-1-[(6-chloro-9-deazapurin-9-yl)methyl]-3-hydroxy-4-(2-phenylethyl)pyrrolidine 
• 871023-69-7 {4-[(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)methyl]phenyl}methanol 
• 871024-30-5 4-chloro-5-ethyl-pyrrolo[3,2-d]pyrimidine 
• 919278-13-0 4-chloro-5-[2-(2-methoxyethoxy)ethyl]-5H-pyrrolo[3,2-d]pyrimidine 
• 919278-23-2 2-chloro-4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)aniline 
• 940308-39-4 N-[1-(3-fluorobenzyl)-1H-indol-5-yl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride 
• 1032632-26-0 5-allyl-4-chloro-5H-pyrrolo[3,2-d]pyrimidine 
• 1026012-16-7 5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidine 
• 1166949-04-7 N-(4-methoxybenzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 
• 63200-56-6 N-benzyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine 
• 1166948-78-2 4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidine 
• 871024-38-3 4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine 
• 1032650-41-1 4-chloro-7-bromo-5H-pyrrolo[3,2-d]pyrimidine 
• 871026-10-7 2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl benzoate 

Relevant articles and documents

Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation

A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold th

COMPOSITIONS AND METHODS FOR THERAPY OF PROSTATE CANCER USING DRUG COMBINATIONS TO TARGET POLYAMINE BIOSYNTHESIS AND RELATED PATHWAYS

Provided are compositions and methods for treating prostate conditions. The methods involve administering to an individual in need thereof a composition that contains i) an inhibitor of methionine salvage pathway in prostate of the individual and ii) a polyamine analogue. The methods are for use in individuals who have been diagnosed with, or are suspected of having or at risk for developing androgen sensitive prostate cancer (AS-CaP), or Castration recurrent CaP (CR-CaP), or benign prostate hyperplasia (BPH). The disclosure includes use of inhibitors of methylthioadenosine phosphorylase (MTAP), and a polyamine analog that upregulates polyamine catabolism by increasing spermidine/spermine Nl -acetyl transferase (SAT1) activity, such as methylthio-DADMe-Immucillin (MTDIA), andl),N(11)-bisethylnorspermine (BENSpm), respectively. Pharmaceutical formulations that contain a combination of the inhibitor of the methionine salvage pathway and a polyamine analogue are included, as are kits that contain such agents.

NOVEL PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION INCLUDING SAME AS AN ACTIVE INGREDIENT

The present invention relates to a compound represented by formula (I) for inhibiting the activity of diacylglycerol O-acyltransferase type 1 (DGAT1), and pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising same as an active ingredient. The compound of the present invention may be used effectively in the treatment or prevention of a disease or condition mediated by the activity of DGAT1 such as obesity, type II diabetes, dyslipidemia, metabolic syndrome, and the like, without any adverse effects: wherein A, B, X, and R5 to R7 are the same as defined in the specification.