849062-37-9

Basic information

• Product Name: 3-Bromo-5-fluorophenylboronic acid
• Synonyms: 3-BROMO-5-FLUOROBENZENEBORONIC ACID 95;3-Bromo-5-fluorobenzeneboronic acid 95%;3-Bromo-5-fluorobenzeneboronic acid;3-Bromo-5-fluorophenylboronic acid
• CAS NO: 849062-37-9
• Molecular Formula: C₆H₅BBrFO₂
• Molecular Weight: 218.82
• Product Categories: blocks;BoronicAcids;Aryl;Boronic Acids;Boronic Acids and Derivatives
• Mol File: 849062-37-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: >300
• Boiling Point: 329.035 °C at 760 mmHg
• Flash Point: 152.795 °C
• Appearance: /
• Density: 1.75 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Keep Cold
• PKA: 6.52±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-Bromo-5-fluorophenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-fluorophenylboronic acid(849062-37-9)
• EPA Substance Registry System: 3-Bromo-5-fluorophenylboronic acid(849062-37-9)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 849062-37-9(Hazardous Substances Data)

Usage

Description

3-Bromo-5-fluorophenylboronic acid is an organic compound that features a boron atom bonded to a phenyl ring with a bromine atom at the 3-position and a fluorine atom at the 5-position. This unique structure endows it with versatile reactivity and properties, making it a valuable intermediate in organic synthesis and a building block for the development of various functional materials.

Uses

Used in Organic Synthesis:
3-Bromo-5-fluorophenylboronic acid is used as a reactant for the preparation of functionalized dihalophenylboronic acids. It serves as a key intermediate in the synthesis of complex organic molecules and pharmaceutical compounds, providing a convenient route to access diverse chemical structures with potential applications in various fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Bromo-5-fluorophenylboronic acid is used as a building block for the development of new drugs. Its unique structure allows for the creation of novel compounds with specific biological activities, potentially leading to the discovery of new therapeutic agents for the treatment of various diseases.
Used in Material Science:
3-Bromo-5-fluorophenylboronic acid is also utilized in material science for the synthesis of functional materials with tailored properties. Its reactivity and structural features enable the design of new materials with improved performance in areas such as electronics, optoelectronics, and energy storage.
Used in Chemical Research:
In chemical research, 3-Bromo-5-fluorophenylboronic acid is employed as a model compound to study various reaction mechanisms and explore new synthetic methodologies. Its unique reactivity allows researchers to gain insights into the fundamental aspects of organic chemistry and develop innovative strategies for the synthesis of complex molecules.

InChI:InChI=1/C6H5BBrFO2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,10-11H

Upstream product

• 1435-51-4 1,3-dibromo-5-fluorobenzene 

Downstream Products

• 7631-86-9 SiO₂ 
• 1613643-93-8 C₅₂H₆₈F₂N₄O₈ 
• 1160684-45-6 N-{[8-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine 
• 1160685-34-6 ethyl N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate 
• 1160685-35-7 ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate 

Relevant articles and documents

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.