849068-50-4

Basic information

• Product Name: 6-CHLORO-1-ETHOXYCARBONYL-7-AZAINDOLE
• Synonyms: 6-CHLORO-1-ETHOXYCARBONYL-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 6-chloro-, ethyl ester;ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
• CAS NO: 849068-50-4
• Molecular Formula: C10H9ClN2O2
• Molecular Weight: 224.646
• Mol File: 849068-50-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 343.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.66±0.30(Predicted)
• CAS DataBase Reference: 6-CHLORO-1-ETHOXYCARBONYL-7-AZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-1-ETHOXYCARBONYL-7-AZAINDOLE(849068-50-4)
• EPA Substance Registry System: 6-CHLORO-1-ETHOXYCARBONYL-7-AZAINDOLE(849068-50-4)

Safety Data

• Hazardous Substances Data: 849068-50-4(Hazardous Substances Data)

Usage

General Description

6-CHLORO-1-ETHOXYCARBONYL-7-AZAINDOLE is a chemical compound that belongs to the category of indole derivatives. It is characterized by a six-membered ring structure with a chlorine atom at the 6 position, and an ethoxycarbonyl group at the 1 position. The presence of the azaindole core confers unique properties to this compound, making it of interest in various fields such as medicinal chemistry and material science. Its molecular structure and functional groups make it suitable for the development of pharmaceutical agents with potential therapeutic applications. Additionally, it may also serve as a valuable intermediate in the synthesis of other compounds with specific properties and applications.

Upstream product

• 79-22-1 methyl chloroformate 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 272-49-1 1H-pyrrolo[3,2-b]pyridine 
• 271-63-6 7-Azaindole 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 1296200-79-7 N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide 
• 915140-96-4 6-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 
• 1296203-11-6 C₁₆H₁₄ClN₃O₂ 
• 824-51-1 6-methyl-1H-pyrrolo<2,3-b>pyridine 
• 1420532-28-0 5-bromo-2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)benzonitrile 
• 1420532-29-1 (5-bromo-2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)methanamine 
• 1420532-35-9 1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1000340-28-2 3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1420532-46-2 tert-butyl 2-(1-(2-(acetamidomethyl)-4-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate 
• 1420532-47-3 tert-butyl 2-(1-(2-(ethanethioamidomethyl)-4-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate 
• 1420532-48-4 ?tert-butyl 2-(1-(2-((3,5-dimethyl-4H-1,2,4-triazol-4-yl)methyl)-4-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate 
• 1420070-69-4 N-ethyl-N-(5-(trifluoromethyl)-2-(6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)benzyl)cyclopropanecarboxamide 
• 1420070-56-9 N-[2-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide 
• 1420532-25-7 N-ethyl-N-(2-(6-ethyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl)cyclopropanecarboxamide 

Relevant articles and documents

COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES

The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases

NEW CRTH2 ANTAGONISTS

The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Rho kinase (ROCK) inhibitors are potential therapeutic agents to treat disorders such as hypertension, multiple sclerosis, cancers, and glaucoma. Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC 50 = 1 nM) with 740-fold selectivity over PKA (47). Moreover, 47 showed very good DMPK properties making it a good candidate for further development. Finally, docking studies with a homology model of ROCK-II were performed to rationalize the binding mode of these compounds and showed the compounds bound in both orientations to take advantage to H-bonds with Lys-121 of ROCK-II.