849107-20-6

Basic information

• Product Name: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE
• Synonyms: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE;1-Chloro-2-[(piperidine-4-yl)oxy]benzene hydrochloride;4-(2-Chlorophenoxy)piperidiniuM chloride;Piperidine,4-(2-chlorophenoxy)-,hydrochloride;Piperidine, 4-(2-chlorophenoxy)-, hydrochloride (1:1)
• CAS NO: 849107-20-6
• Molecular Formula: C11H15Cl2NO
• Molecular Weight: 248.15
• Mol File: 849107-20-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE(849107-20-6)
• EPA Substance Registry System: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE(849107-20-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 849107-20-6(Hazardous Substances Data)

Usage

General Description

4-(2-Chlorophenoxy)piperidine hydrochloride is a chemical compound with a specific molecular structure. 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE has significance in the field of organic chemistry and can serve various scientific research purposes. It consists of a piperidine ring, which is a common feature in many pharmaceuticals and natural products, attached to a chlorophenoxy group. The presence of the hydrochloride group suggests this compound is a hydrochloride salt, which generally improves the water solubility of organic compounds and is often found in pharmaceuticals. Like many compounds of this nature, careful handling is essential due to potential reactivity and toxicity.

Upstream product

• 552868-10-7 4-(2-chloro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 900512-07-4 1-benzyl-4-(2-chloro-phenoxy)piperidine 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 95-57-8 2-monochlorophenol 

Downstream Products

• 944240-42-0 C₁₉H₂₁ClN₄O₄ 
• 944240-57-7 C₂₀H₂₂ClN₃O₄ 

Relevant articles and documents

NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS

Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

DERIVATIVES OF 2H PYRIDAZIN- 3 -ONES, THEIR PREPARATION AND THEIR USE AS SCD-1 INHIBITORS

The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: -R1 represents one or more groups such as: trif luoromethyl, halogen such as F, C1, -when n=m=1, W represents CH then Y represents oxygen, -U represents: ? either - (C=O) CH2NH- and is branched at position 4 of pyridazinone, then R2 represents H, ? or -(C=O)NH- and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, - R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enyzme inhibitors for the treatment of obesitz, tzpe-2 diabetes and lipid disorders.

Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors

A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitors. 4-(2-Chlorophenoxy)-N-[3-(methyl carbamoyl)phenyl]piperidine-1-carboxamide 4c exhibited robust in vivo activity with dose-dependent desaturation index lowering effects.