84946-09-8 Usage
Description
(8alpha,9R)-10,11-dihydro-6'-methoxy-5'-nitrocinchonan-9-ol is a chemical compound that belongs to the family of cinchona alkaloids. It is a derivative of cinchonine, a natural product found in the bark of the cinchona tree known for its medicinal properties. (8alpha,9R)-10,11-dihydro-6'-methoxy-5'-nitrocinchonan-9-ol features a hydroxyl group at position 9, a nitro group at position 5, and a methoxy group at position 6' on the cinchonan ring. Its unique structure and functional groups make it a promising candidate for medicinal chemistry and drug development, given the pharmacological activities of cinchona alkaloids, such as anti-malarial, antiarrhythmic, and antimalarial properties.
Uses
Used in Medicinal Chemistry:
(8alpha,9R)-10,11-dihydro-6'-methoxy-5'-nitrocinchonan-9-ol is used as a compound in medicinal chemistry for its potential therapeutic applications. Its unique structure and functional groups contribute to its pharmacological activities, making it a valuable candidate for the development of new drugs.
Used in Drug Development:
In the field of drug development, (8alpha,9R)-10,11-dihydro-6'-methoxy-5'-nitrocinchonan-9-ol is used as a starting material for the synthesis of new pharmaceuticals. Its presence in the cinchona alkaloid family and the known medicinal properties of related compounds suggest that it may have potential uses in creating effective treatments for various diseases and conditions.
Used in Antimalarial Applications:
(8alpha,9R)-10,11-dihydro-6'-methoxy-5'-nitrocinchonan-9-ol is used as an antimalarial agent due to the known anti-malarial properties of cinchona alkaloids. Its specific functional groups may provide a unique profile for combating malaria, offering a potential new avenue for treatment.
Used in Antiarrhythmic Applications:
As part of the family of cinchona alkaloids, which are known for their antiarrhythmic properties, (8alpha,9R)-10,11-dihydro-6'-methoxy-5'-nitrocinchonan-9-ol is used in the development of antiarrhythmic medications. Its structure may contribute to the regulation of heart rhythm, providing a new option for treating arrhythmias.
Used in Antimicrobial Applications:
Given the broad range of pharmacological activities within the cinchona alkaloid family, (8alpha,9R)-10,11-dihydro-6'-methoxy-5'-nitrocinchonan-9-ol may also be used in antimicrobial applications. Its potential to combat microbial infections could lead to the development of new antibiotics or antifungal agents.
Check Digit Verification of cas no
The CAS Registry Mumber 84946-09-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,9,4 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 84946-09:
(7*8)+(6*4)+(5*9)+(4*4)+(3*6)+(2*0)+(1*9)=168
168 % 10 = 8
So 84946-09-8 is a valid CAS Registry Number.
84946-09-8Relevant articles and documents
Asymmetric α-Hydroxylation of β-Indanone Esters and β-Indanone Amides Catalyzed by C-2′ Substituted Cinchona Alkaloid Derivatives
Wang, Yakun,Yin, Hang,Qing, Hai,Zhao, Jingnan,Wu, Yufeng,Meng, Qingwei
supporting information, p. 737 - 745 (2016/03/09)
The highly catalytic asymmetric α-hydroxylation of β-indanone esters and β-indanone amides using peroxide as the oxidant was realized with a new C-2′ substituted Cinchona alkaloid derivatives. The two enantiomers of α-hydroxy-β-indanone esters could be obtained by simply changing the oxidant. This protocol allows a convenient access to the corresponding α-hydroxy-β-indanone esters and α-hydroxy-β-indanone amides with up to 99% yield and 98% ee.
A new class of urea-substituted cinchona alkaloids promote highly enantioselective nitroaldol reactions of trifluoromethylketones
Palacio, Carole,Connon, Stephen J.
supporting information; experimental part, p. 1298 - 1301 (2011/05/03)
The first class of bifunctional cinchona-alkaloid catalysts incorporating a urea moiety at C-5′ has been developed. These materials catalyze the efficient and highly enantioselective 1,2-addition of nitromethane to trifluoromethylketones to form synthetically pliable products incorporating a quaternary stereocenter. Excellent product yields and levels of enantiomeric excess are possible, and the optimum catalyst structure is capable of promoting the Henry reaction involving alkyl trifluoromethylketones with unprecedented enantioselectivity.
