84951-44-0

Basic information

• Product Name: 2-PIPERAZINONICOTINONITRILE
• Synonyms: RARECHEM AH CK 0176;TIMTEC-BB SBB005548;BUTTPARK 99\12-41;2-(1-PIPERAZINYL)-3-PYRIDINECARBONITRILE;2-PIPERAZINONICOTINONITRILE;2-PIPERAZIN-1-YLNICOTINONITRILE;2-(PIPERAZIN-1-YL)-3-PYRIDINECARBONITRILE;1-[2-(3-CYANOPYRIDYL)]PIPERAZINE
• CAS NO: 84951-44-0
• Molecular Formula: C₁₀H₁₂N₄
• Molecular Weight: 188.23
• Product Categories: PIPERIDINE;Piperidines, Piperidones, Piperazines;pharmacetical
• Mol File: 84951-44-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 102-104°C
• Boiling Point: 388 °C at 760 mmHg
• Flash Point: 188.4 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 3.17E-06mmHg at 25°C
• Refractive Index: 1.605
• PKA: 8.34±0.10(Predicted)
• CAS DataBase Reference: 2-PIPERAZINONICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERAZINONICOTINONITRILE(84951-44-0)
• EPA Substance Registry System: 2-PIPERAZINONICOTINONITRILE(84951-44-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-34-22
• Safety Statements: 26-36/37/39-45
• RIDADR: 3439
• HazardClass: IRRITANT
• Hazardous Substances Data: 84951-44-0(Hazardous Substances Data)

Usage

General Description

2-Piperazinoniconitonitrile is a chemical compound that can be identified by its molecular structure and index name. It falls under the category of organic compounds, specifically nitrogen-containing heterocyclic compounds. It's characterized by a piperazine ring, a six-membered ring structure containing two nitrogen atoms. Its formula is C9H11N5 and its systematic name is 1-(3-cyanopyridin-2-yl)piperazine. This chemical is utilized in various scientific research processes and industrial applications, but its exact uses are not commonly specified in general resources. Due to its unique structure, it can be used to create various derivatives, which serve as key intermediate compounds in chemical syntheses. Information about its hazards or safety profiles are not readily available; therefore, it is advisable to handle it with care following standard scientific or industrial safety protocols.

InChI:InChI=1/C10H12N4/c11-8-9-2-1-3-13-10(9)14-6-4-12-5-7-14/h1-3,12H,4-7H2

Upstream product

• 110-85-0 piperazine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Downstream Products

• 630116-08-4 2-[4-(3-cyano-2-pyridinyl)-1-piperazinyl]-N-(3-methylphenyl)acetamide 
• 861965-27-7 2-[4-(3-oxo-3-phenylpropyl)piperazin-1-yl]nicotinonitrile 
• 393515-65-6 4-(3-Cyano-2-pyridinyl)-N-[4-(isopropyl)phenyl]-1-piperazinecarboxamide 
• 104842-73-1 2-(piperazin-1-yl)nicotinaldehyde 

Relevant articles and documents

Structure guided design of potential inhibitors of human calcium-calmodulin dependent protein kinase IV containing pyrimidine scaffold

Calmodulin dependent protein kinase IV (CAMKIV) belongs to the serine/threonine protein kinase family and considered as an encouraging target for the development of novel anticancer agents. The interaction and binding behavior of three designed inhibitors

Quinoline carboxamide core moiety-based compounds inhibit P. falciparum falcipain-2: Design, synthesis and antimalarial efficacy studies

Targeting Falcipain-2 (FP2) for the development of antimalarials is a promising and established concept in antimalarial drug discovery and development. FP2, a member of papain-family cysteine protease of the malaria parasite Plasmodium falciparum holds an important role in hemoglobin degradation pathway. A new series of quinoline carboxamide-based compounds was designed, synthesized and evaluated for antimalarial activity. We integrated molecular hybridization strategy with in-silico drug design to develop FP2 inhibitors. In-vitro results of FP2 inhibition by Qs17, Qs18, Qs20 and Qs21 were found to be in low micromolar range with IC50 4.78, 7.37, 2.14 and 2.64 μM, respectively. Among the 25 synthesized compounds, four compounds showed significant antimalarial activities. These compounds also depicted morphological and food-vacuole abnormalities much better than that of E-64, an established FP2 inhibitor. Overall these aromatic substituted quinoline carboxamides can serve as promising leads for the development of novel antimalarial agents.

Substituted indole compound and method and use thereof

The invention provides a new indole compound, pharmaceutically acceptable salts and medicinal preparations thereof, and a use of the new indole compound in selective inhibition of 5-hydroxytryptamine reuptake and /or excitation of a 5-HT1A receptor. The invention also relates to medicinal compositions comprising the compounds, and a method for treating the central nervous system dysfunction of mammals, especially humans by using the medicinal compositions.