84960-32-7

Basic information

• Product Name: 2-[6-(1-Cyano-1-phenyl-propyl)-pyridin-2-yl]-2-phenyl-butyronitrile
• CAS NO: 84960-32-7
• Molecular Weight: 365.478
• Mol File: 84960-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[6-(1-Cyano-1-phenyl-propyl)-pyridin-2-yl]-2-phenyl-butyronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[6-(1-Cyano-1-phenyl-propyl)-pyridin-2-yl]-2-phenyl-butyronitrile(84960-32-7)
• EPA Substance Registry System: 2-[6-(1-Cyano-1-phenyl-propyl)-pyridin-2-yl]-2-phenyl-butyronitrile(84960-32-7)

Safety Data

• Hazardous Substances Data: 84960-32-7(Hazardous Substances Data)

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 769-68-6 2-phenylbutanenitrile 

Relevant articles and documents

SRN1 Mechanism in Heteroaromatic Nucleophilic Substitution. Reactions Involving Certain Dihalogenated ?-Deficient Nitrogen Heterocycles

Photostimulated reactions of 2,6-,2,3-, 3,5-, and 2,5-dihalopyridines (1a-e) with pinacolone potassium enolate (2) in liquid NH3 lead to facile replacement of both halogens via a modified SRN1 mechanism, which does not involve intermediate formation of monosubstitution products.The potassium salts of phenylacetonitrile (12a) and α-ethylphenylacetonitrile (12b) react with 2,6-dibromopyridine (1a) under similar conditions to afford a mixture of mono- and disubstituted products via a related SRN1 process. 4,7-Dichloroquinoline (16) undergoes radical-chain displacement of chloride from C4 with enolate 2. 2,6-Dichloropyrazine (18) and 2,3-dichloropyrazine (20) also undergo monosubstitution with 2 and diisopropyl ketone potassium enolate (22), but these reactions appear to be mainly addition-elimination (SNAr) processes.Treatment of 3,6-dichloropyridazine (27) with 22 results in addition of 22 to C4 of the substrate.Photoassisted reaction of 2,4-dichloropyrimidine (31) with 12a leads to exclusive chloride displacement from C4 via the SRN1 mechanism.