849600-52-8

Basic information

• Product Name: 4(1H)-Pyrimidinone, 6-hydroxy-2-pyrazinyl-5-(2,4,6-trifluorophenyl)-
• CAS NO: 849600-52-8
• Molecular Formula: C14H7F3N4O2
• Molecular Weight: 320.23
• Mol File: 849600-52-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4(1H)-Pyrimidinone, 6-hydroxy-2-pyrazinyl-5-(2,4,6-trifluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 6-hydroxy-2-pyrazinyl-5-(2,4,6-trifluorophenyl)-(849600-52-8)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 6-hydroxy-2-pyrazinyl-5-(2,4,6-trifluorophenyl)-(849600-52-8)

Safety Data

• Hazardous Substances Data: 849600-52-8(Hazardous Substances Data)

Upstream product

• 262609-07-4 diethyl (2,4,6-trifluoro-phenyl)-malonate 
• 138588-41-7 pyrazine-2-carboxamidine hydrochloride 
• 200928-43-4 2-carbamidinopyrazine 

Downstream Products

• 849600-02-8 6-chloro-2-(pyrazin-2-yl)-N-(2,2,2-trifluoroethyl)-5-(2,4,6-trifluorophenyl)pyrimidin-4-amine 
• 1584641-89-3 (S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine 
• 461678-27-3 6-chloro-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-5-(2,4,6-trifluorophenyl)pyrimidin-4-amine 
• 849600-51-7 4,6-dichloro-2-(pyrazin-2-yl)-5-(2,4,6-trifluorophenyl)pyrimidine 

Relevant articles and documents

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Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents

The synthesis and SAR of a series of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents are described. This series of 2-heteroarylpyrimidines was developed by modifying a series of anti-tumor [1,2,4]triazolo[1,5-a]pyrimidines and 2-cyanoaminopyrimidines we reported earlier. For the 2-heteroaryl group, the best activity is obtained when the heteroaryl group has a nitrogen atom at the ortho-position to the pyrimidyl core. The structure-activity relationship for the rest of the molecule in this 2-heteroarylpyrimidine series mimics that of the [1,2,4]triazolo[1,5-a]pyrimidine series. Like triazolopyrimidines and 2-cyanoaminopyrimidines, the 2-heteroarylpyrimidines retain the capability to overcome multidrug resistance due to Pgp. Mechanism of action studies showed that the lead compounds behaved in the same manner as triazolopyrimidines and 2-cyanoaminopyrimidines. The lead compounds in this series are more potent than the corresponding triazolopyrimidines in vitro and in vivo. Compound 21 (PTI-868) showed tumor growth inhibition in several nude mouse xenograft models, and was selected to advance to preclinical development.

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This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for