84966-80-3

Basic information

• Product Name: 2-(2-chlorophenyl)-N,N-dimethylacetamide
• Synonyms: 2-(2-chlorophenyl)-N,N-dimethylacetamide
• CAS NO: 84966-80-3
• Molecular Weight: 197.664
• Mol File: 84966-80-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(2-chlorophenyl)-N,N-dimethylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chlorophenyl)-N,N-dimethylacetamide(84966-80-3)
• EPA Substance Registry System: 2-(2-chlorophenyl)-N,N-dimethylacetamide(84966-80-3)

Safety Data

• Hazardous Substances Data: 84966-80-3(Hazardous Substances Data)

Upstream product

• 28321-11-1 1-chloro-2-(2,2-difluorovinyl)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 124-40-3 dimethyl amine 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 

Downstream Products

• 142733-20-8 1-[1-(2-chlorophenyl)-2-(dimethylamino)ethyl]cyclohexanol 

Relevant articles and documents

Direct defluorinative amidation-hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

A novel and efficient method for the synthesis of arylacetamides by the reactions of gem-difluoroalkenes with N,N-dialkylformamides, and primary and secondary amines with the assistance of KOtBu and water was developed.

2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: Synthesis and antidepressant activity

A series of 2-phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives was examined for the ability to inhibit both rat brain imipramine receptor binding and the synaptosomal uptake of norepinephrine (NE) and serotonin (5-HT). Neurotransmitter uptake inhibition was highest for a subset of 2-phenyl-2-(1-hydroxycyclohexyl)dimethylethylamines in which the aryl ring has a halogen or methoxy substituent at the 3- and/or 4-positions. Potential antidepressant activity in this subset was assayed in three rodent models - the antagonism of reserpine-induced hypothermia, the antagonism of histamine-induced ACTH release, and the ability to reduce noradrenergic responsiveness in the rat pineal gland. An acute effect seen in the rat pineal gland with several analogues, including 1-[1-(3,4-dichlorophenyl)-2-(dimethylamino)ethyl]cyclohexanol (23) and 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol (4), was taken as a possible correlate of a rapid onset of antidepressant activity. Compound 4 (venlafaxine) is presently undergoing clinical evaluation.