849668-91-3

Basic information

• Product Name: BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-
• Synonyms: BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-;2-AMino-N-[4-[2-(6,7-diMethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-4,5-diMethoxybenzaMide
• CAS NO: 849668-91-3
• Molecular Formula: C₂₈H₃₃N₃O₅
• Molecular Weight: 491.57872
• Mol File: 849668-91-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-(849668-91-3)
• EPA Substance Registry System: BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-(849668-91-3)

Safety Data

• Hazardous Substances Data: 849668-91-3(Hazardous Substances Data)

Usage

Description

BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxyis a complex organic compound that serves as an intermediate in the synthesis of Tariquidar (T007600), a P-glycoprotein drug efflux pump inhibitor. BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxyis characterized by its unique molecular structure, which includes a benzamide core with various substituents, such as amino, isoquinolinyl, and dimethoxy groups. Its role in the synthesis of Tariquidar highlights its potential applications in the pharmaceutical industry, particularly in the development of cancer treatments.

Uses

Used in Pharmaceutical Industry:
BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxyis used as an intermediate in the synthesis of Tariquidar (T007600) for its potential application in cancer treatment. Tariquidar is a P-glycoprotein drug efflux pump inhibitor, which can help overcome multidrug resistance in cancer cells by inhibiting the efflux of chemotherapeutic agents, thereby increasing their intracellular concentration and effectiveness. This makes BenzaMide a valuable component in the development of novel cancer therapies and improving the efficacy of existing treatments.

Upstream product

• 82925-02-8 4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine 
• 82925-01-7 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[2-(4-nitrophenyl)ethyl]-isoquinoline 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 29568-78-3 4,5-dimethoxy-2-nitrobenzoyl chloride 
• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 
• 1024592-54-8 N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxy-2-nitro-benzamide 

Downstream Products

• 206873-63-4 tariquidar 

Relevant articles and documents

DEUTERATED ANALOGS OF TARIQUIDAR

The present invention relates to efflux inhibitor compounds, compositions, and methods of using the same. More specifically, the instant invention comprises deuterated analogs of tariquidar with superior pharmacokinetic properties such that it is now poss

NOVEL P-GLYCOPROTEIN INHIBITOR, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

A p-glycoprotein inhibitor of Formula 1 is capable of effectively preventing the development of multi-drug resistance directed to an anticancer agent in cancer cells, and greatly enhances the bioavailability of the drug, such as paclitaxel, which is not readily absorbed when orally administered.