849693-82-9

Basic information

• Product Name: Phosphonic acid, [2-oxo-2-(1-pyrrolidinyl)ethyl]-, diphenyl ester
• CAS NO: 849693-82-9
• Molecular Formula: C18H20NO4P
• Molecular Weight: 345.335
• Mol File: 849693-82-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [2-oxo-2-(1-pyrrolidinyl)ethyl]-, diphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [2-oxo-2-(1-pyrrolidinyl)ethyl]-, diphenyl ester(849693-82-9)
• EPA Substance Registry System: Phosphonic acid, [2-oxo-2-(1-pyrrolidinyl)ethyl]-, diphenyl ester(849693-82-9)

Safety Data

• Hazardous Substances Data: 849693-82-9(Hazardous Substances Data)

Upstream product

• 20266-00-6 chloroacetic acid pyrrolidide 
• 4712-55-4 diphenyl hydrogen phosphite 

Downstream Products

• 19202-21-2 1-trans-cinnamoylpyrrolidine 
• 240805-44-1 (Z)-1-(1-oxo-3-phenyl-2-propenyl)pyrrolidine 

Relevant articles and documents

Synthesis of β-monosubstituted α,β-unsaturated amides with z-selectivity using diphenylphosphonoacetamides

The utility of diphenylphosphonoacetamides [(PhO)2P(O)CH 2CONRR′] as Horner-Wadsworth-Emmons reagents was examined with five different patterns of substitution upon the amide nitrogen atom (2a: R, R′ = CH2Ph; 2b: R = CH2Ph, R′ = H; 2c: R = Me, R′ = OMe; 2d: R, R′ = Ph; 2e: R, R′ = (CH2) 4). The reaction of 2a was found to be Z-selective for aromatic aldehydes with selectivities up to 95:5. Reagent 2b led to reasonable selectivity for both benzaldehyde (85:15) and 3-phenylpropionaldehyde (87:13), while 2c was somewhat effective for only the latter alkyl aldehyde (83:17). Compounds 2d and 2e exhibited slightly lower selectivities compared with 2a.