849727-15-7

Basic information

• Product Name: Benzeneacetamide, 2-fluoro-N-[(1R)-2-hydroxy-1-phenylethyl]-
• CAS NO: 849727-15-7
• Molecular Formula: C16H16FNO2
• Molecular Weight: 273.307
• Mol File: 849727-15-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzeneacetamide, 2-fluoro-N-[(1R)-2-hydroxy-1-phenylethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, 2-fluoro-N-[(1R)-2-hydroxy-1-phenylethyl]-(849727-15-7)
• EPA Substance Registry System: Benzeneacetamide, 2-fluoro-N-[(1R)-2-hydroxy-1-phenylethyl]-(849727-15-7)

Safety Data

• Hazardous Substances Data: 849727-15-7(Hazardous Substances Data)

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 451-82-1 (2-fluorophenyl)acetic acid 

Downstream Products

• 849727-16-8 (S)-2-(2-Fluoro-benzyl)-4-phenyl-4,5-dihydro-thiazole 

Relevant articles and documents

Efficient synthesis of bicyclic oxazolino- and thiazolino[3,2-c]pyrimidine- 5,7-diones and its application to the synthesis of GnRH antagonists

Treatment of various 2-methyl oxazolines or thiazolines with chlorocarbonyl isocyanate gives the corresponding bicyclic oxazolino- or thiazolino[3,2-c] pyrimidin-5,7-dione derivatives in very good yield. This reaction has been applied to the rapid syntheses of human gonadotropin-releasing hormone (hGnRH) receptor antagonists for SAR study, resulting in 13e with binding affinity in the low nanomolar range (4.5 nM).