849727-62-4

Basic information

• Product Name: 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride
• Synonyms: 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride
• CAS NO: 849727-62-4
• Molecular Formula: C₁₁H₁₁ClN₂O₂*ClH
• Molecular Weight: 275.13118
• Mol File: 849727-62-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.6g/cm3 at 20℃
• Vapor Pressure: 0-0Pa at 20-25℃
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride(849727-62-4)
• EPA Substance Registry System: 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride(849727-62-4)

Safety Data

• Hazardous Substances Data: 849727-62-4(Hazardous Substances Data)

Usage

Uses

3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-a]pyrimidin-4-one Hydrochloride is an intermediate in the synthesis of analog of Paliperidone (P141000), a combined serotonin and dopamine receptor antagonist.

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 24016-03-3 2-amino-3-benzyloxypyridine 
• 10025-87-3 trichlorophosphate 
• 181525-38-2 9-hydroxy-3-hydroxyethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 147687-17-0 9-(benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 

Downstream Products

• 130049-82-0 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 
• 849727-63-5 (±)-3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride 
• 260273-82-3 3-(2-chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one 
• 130049-85-3 (+)-Paliperidone 
• 1138463-56-5 3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one 
• 849903-79-3 3-ethyl-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 

Relevant articles and documents

Preparation of 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, a Key Intermediate for the Synthesis of Paliperidone

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NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF PALIPERIDONE

The present invention relates to a novel process for the preparation of paliperidone and its intermediates and also relates to an improved process for the preparation of paliperidone compound of formula (I).

PROCESS OF SYNTHESIS OF PALIPERIDONE

The invention relates to an improved process for preparation of 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one, an intermediate used in the synthesis of paliperidone and process for converting the same to Paliperidone.