849745-54-6Relevant articles and documents
Identification of a tunable site in bryostatin analogs: C20 bryologs through late stage diversification
Wender, Paul A.,Baryza, Jeremy L.
, p. 1177 - 1180 (2007/10/03)
The C20 region of our bryostatin analogs was identified as a nonpharmacophoric site that could be varied to tune analogs for function and physical properties without significantly affecting their binding affinity for PKC. The use of this site in a late-stage diversification strategy has enabled the facile synthesis of a variety of new C20 analogs, all of which retain nanomolar affinity for PKC, in agreement with our pharmacophore hypothesis.