849811-78-5

Basic information

• Product Name: Pitavastatin Methyl Ester
• Synonyms: Pitavastatin Methyl Ester;(3R,5S,E)-Methyl 7-(2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl)-3,5-dihydroxyhept-6-enoate;Methyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoate;DOLM;(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid methyl ester;sodium,(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
• CAS NO: 849811-78-5
• Molecular Formula: C₂₆H₂₆FNO₄
• Molecular Weight: 435.4873432
• Mol File: 849811-78-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Pitavastatin Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pitavastatin Methyl Ester(849811-78-5)
• EPA Substance Registry System: Pitavastatin Methyl Ester(849811-78-5)

Safety Data

• Hazardous Substances Data: 849811-78-5(Hazardous Substances Data)

Usage

Description

Pitavastatin Methyl Ester is the methyl ester derivative of Pitavastatin, a competitive inhibitor of HMG-CoA reductase and an antilipemic agent. It is a lipid-lowering medication used to treat high cholesterol levels and reduce the risk of cardiovascular diseases.

Uses

Used in Pharmaceutical Industry:
Pitavastatin Methyl Ester is used as a pharmaceutical agent for the treatment of hyperlipidemia. It works by inhibiting the enzyme HMG-CoA reductase, which is responsible for cholesterol synthesis in the liver, thereby reducing the levels of low-density lipoprotein (LDL) cholesterol and triglycerides in the blood.
Used in Cardiovascular Disease Prevention:
Pitavastatin Methyl Ester is used as a preventive measure for cardiovascular diseases. By lowering the levels of LDL cholesterol and triglycerides, it helps to reduce the risk of atherosclerosis, heart attacks, and strokes.
Used in Combination Therapy:
Pitavastatin Methyl Ester can be used in combination with other medications, such as ezetimibe, to enhance the reduction of cholesterol levels and improve the overall management of hyperlipidemia.
Used in Research and Development:
Pitavastatin Methyl Ester is also used in research and development for the study of cholesterol metabolism, the development of new drugs, and the investigation of potential synergistic effects with other medications.

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 32249-35-7 methyl 3-cyclopropyl-3-oxopropanoate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 121660-11-5 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 
• 121660-37-5 2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline 
• 765-43-5 Cyclopropyl methyl ketone 
• 164576-45-8 (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid methyl ester 
• 140164-51-8 methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxane-4-yl)acetate 

Downstream Products

• 147526-32-7 pitavastatin calcium salt 
• 147526-32-7 pitavastatin 
• 1213706-08-1 (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt 

Relevant articles and documents

Substrate stereocontrol in bromine-induced intermolecular cyclization: Asymmetric synthesis of pitavastatin calcium

A novel approach to synthesize pitavastatin calcium (1), an effective HMG-CoA reductase inhibitor, based on readily available and attractively functionalized (R)-3-chloro-1,2-propanediol is reported. This work highlights an intermolecular diastereoselective bromine-induced cyclization of homoallylic carbonate to meet stereochemical challenges in the synthesis of statins. An efficient route to a new triphenylphosphonium tetrafluoroborate salt of a quinoline core is also presented.

PROCESS FOR PREPARING STATINS

Process for the preparation of β-ketoester synthetic intermediates useful in the preparation of statins, in particular Pitavastatin.