849948-90-9Relevant articles and documents
Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction
Merkx, Remco,Brouwer, Arwin J.,Rijkers, Dirk T. S.,Liskamp, Rob M. J.
, p. 1125 - 1128 (2005)
(Chemical Equation Presented) A highly efficient coupling of protected β-substituted aminoethane sulfonyl azides with thio acids is reported. In the case of peptide thio acids, this method encompasses a new chemoselective ligation method. Furthermore, the
'Sulfo-click' for ligation as well as for site-specific conjugation with peptides, fluorophores, and metal chelators
Rijkers, Dirk T. S.,Merkx, Remco,Yim, Cheng-Bin,Brouwer, Arwin J.,Liskamp, Rob M. J.
scheme or table, p. 1 - 5 (2010/11/04)
The 'sulfo-click' reaction, which is a chemoselective amidation reaction involving the reaction of an aminoethane sulfonyl azide with a thio acid, encompasses a new approach for ligation and conjugation. Detailed protocols are provided for decorating biol